| Name | UBE2I |
|---|---|
| Description | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) |
| Owner | Public |
| URN | urn:agi-llid:7329 |
| Connectivity | 65 |
| Notes | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| Hugo ID | 12485 |
| Microarray ID | 855 |
|---|---|
| MB794 | |
| 1370250_at | |
| u54632_at | |
| u54632_g_at | |
| A_43_P11682 | |
| 1422712_a_at | |
| A_51_P400909 | |
| A_51_P177897 | |
| A_51_P366400 | |
| A_51_P366406 | |
| 213535_s_at | |
| 213536_s_at | |
| 208760_at | |
| 233360_at | |
| 38480_s_at | |
| 211008_s_at | |
| 1558088_a_at | |
| 33136_at | |
| 838_s_at | |
| N36588_at | |
| U45328_s_at | |
| A_23_P152107 | |
| A_14_P111331 | |
| OR2376 | |
| OH3564A |
| Chromosome position | 10q12 |
|---|---|
| 17 A3.3 | |
| 16p13.3 |
| GO ID | 0004840 |
|---|---|
| 0005515 | |
| 0006464 | |
| 0006511 | |
| 0004842 | |
| 0006512 | |
| 0008642 | |
| 0016874 |
| Alias | similar to ubiquitin-conjugating enzyme 9 (UBC9) |
|---|---|
| similar to ubiquitin-conjugating enzyme UbcE2A | |
| (homologous to yeast UBC9) | |
| ubiquitin-conjugating enzyme E2I (homologous to UBC9) | |
| UBCI | |
| ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | |
| C358B7.1 | |
| PIR:S71113 | |
| ubiquitin conjugating enzyme 9 | |
| ubiquitin conjugating enzyme IX | |
| ubiquitin-conjugating enzyme UbcE2A | |
| ubiquitin-protein ligase E2I | |
| UbcE2A | |
| SUMO-1- protein ligase | |
| Mmubc9s | |
| mgc105476 | |
| ubce2i | |
| Mmubc9 | |
| Ubce9 | |
| Ube2i | |
| ubiquitin-conjugating enzyme E2I | |
| ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9) | |
| Ubiquitin-like protein SUMO-1 conjugating enzyme | |
| 5830467E05Rik | |
| RIKEN cDNA 5830467E05 gene | |
| ubiquitin-conjugating enzyme 9 (UBC9) | |
| homologous to yeast UBC9 | |
| UBCI_HUMAN | |
| ubiquitin conjugating enzyme UBC9 | |
| homologous to UBC9 | |
| Ubiquitin carrier protein (P18) | |
| UBC9 |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Homo sapiens |
| MedLine Reference | 12633878 |
|---|---|
| 9013644 |
| LocusLink ID | 7329 |
|---|---|
| 22196 | |
| 25573 | |
| 76085 |
| FunctionalClass | protein binding |
|---|---|
| ubiquitin conjugating enzyme | |
| ligase | |
| ubiquitin-like activating enzyme | |
| ubiquitin-protein ligase |
| RGD ID | 3926 |
|---|
| Hugo Symbol | UBE2I |
|---|
| Unigene ID | Rn.2274 |
|---|---|
| Mm.240044 | |
| Hs.302903 |
| Cell Localization | Cytoplasm |
|---|
| Pathway | TNFRSF6 -> TP53 signalling pathway |
|---|---|
| TNFSF4-TNFRSF6 | |
| TNFSF5-TNFRSF6 | |
| TNFSF7-TNFRSF6 | |
| TNFSF8-TNFRSF6 | |
| TNFSF9-TNFRSF6 | |
| AR | |
| ERalpha | |
| GR | |
| COUP-TF | |
| NR common regulators | |
| Donna's proteomics |
| GO Biological Process | protein modification |
|---|---|
| ubiquitin-dependent protein catabolism | |
| ubiquitin cycle |
| Group | Ubiquitin ligases |
|---|
| EC Number | 6.3.2.19 |
|---|
| State Description | Transcript Variant: This variant (1) represents the predominant transcript. |
|---|---|
| Transcript Variant: This variant (2) has an additional internal exon in the 5' UTR, as compared to variant 1. | |
| Transcript Variant: This variant (3) has an alternate 5' exon, as compared to variant 1. | |
| Transcript Variant: This variant (4) has an alternate 5' exon, as compared to variant 1. |
| MGI ID | 107365 |
|---|
| Swiss-Prot Accession | P50550 |
|---|
| OMIM ID | 601661 |
|---|
| Source | Curated |
|---|