| Name | YWHAH |
|---|---|
| Description | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide |
| Owner | Public |
| URN | urn:agi-llid:7533 |
| Connectivity | 61 |
| Notes | This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat has been associated with early-onset schizophrenia. |
| Hugo ID | 12853 |
| Microarray ID | 1367693_at |
|---|---|
| d17445_at | |
| d17445_g_at | |
| A_42_P794901 | |
| A_51_P306527 | |
| 201020_at | |
| 236559_at | |
| 242325_at | |
| 1424_s_at | |
| D78577_s_at | |
| rc_h69844_s_at | |
| A_23_P103070 | |
| A_14_P112008 | |
| A_14_P101267 | |
| M71 | |
| OR0226 | |
| 368 | |
| OH3606A | |
| R060 |
| Chromosome position | 14q21 |
|---|---|
| 5 B1 | |
| 22q12.3 |
| GO ID | 0006886 |
|---|---|
| 0007165 | |
| 0019901 | |
| 0042069 | |
| 0007010 | |
| 0007088 | |
| 0008426 | |
| 0009966 | |
| 0019904 | |
| 0043066 | |
| 0045664 | |
| 0048167 | |
| 0003779 | |
| 0005159 | |
| 0005737 | |
| 0006469 |
| Alias | tyrosine 3/tryptophan 5 -monooxygenase activation protein, eta polypeptide |
|---|---|
| tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | |
| YWHA1 | |
| 14-3-3 eta | |
| Ywhah | |
| mgc93547 | |
| tyrosine 3/tryptophan 5 -monooxygenase activating protein, eta polypeptide | |
| tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein, eta | |
| YWHA I | |
| 14-3-3e | |
| tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | |
| similar to 14-3-3 eta chain - rat | |
| similar to 14-3-3 protein eta chain |
| Organism | Human |
|---|---|
| Rattus norvegicus | |
| Mus musculus | |
| Homo sapiens |
| MedLine Reference | 1649368 |
|---|---|
| 12446771 |
| LocusLink ID | 25576 |
|---|---|
| 7533 | |
| 22629 | |
| 194104 |
| FunctionalClass | protein kinase binding |
|---|---|
| actin binding | |
| insulin-like growth factor receptor binding | |
| protein domain specific binding | |
| protein kinase C inhibitor |
| RGD ID | 3978 |
|---|
| Hugo Symbol | YWHAH |
|---|
| Unigene ID | Mm.332314 |
|---|---|
| Rn.3324 | |
| Hs.226755 |
| GO Cellular Component | cytoplasm |
|---|
| Cell Localization | Cytoplasm |
|---|
| Pathway | Antiapoptotic Pathways From IGF-1R |
|---|---|
| ACH-R in apoptosis | |
| RB Tumor Suppressor | |
| BDNF-NCAM1 | |
| BDNF-NGFR | |
| BDNF-NTRK1 | |
| BDNF-NTRK2 | |
| BDNF-NTRK3 | |
| CSF2-CSF2RA | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| NTF3-CNTFR | |
| NTF3-NGFR | |
| NTF3-NTRK1 | |
| NTF3-NTRK2 | |
| NTF3-NTRK3 | |
| SDF1-CD4 | |
| SDF1-IL6ST | |
| GR |
| GO Biological Process | negative regulation of protein kinase activity |
|---|---|
| regulation of catecholamine metabolism | |
| signal transduction | |
| intracellular protein transport | |
| cytoskeleton organization and biogenesis | |
| negative regulation of apoptosis | |
| negative regulation of protein kinase | |
| regulation of mitosis | |
| regulation of neuron differentiation | |
| regulation of signal transduction | |
| regulation of synaptic plasticity |
| Group | Metabolic enzymes |
|---|
| MGI ID | 109194 |
|---|
| Swiss-Prot Accession | Q04917 |
|---|
| OMIM ID | OMIM:113508 |
|---|---|
| 113508 |
| Source | Curated |
|---|