Protein : PIK3R1


Name	PIK3R1
Description	phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
Owner	Public
URN	urn:agi-llid:5295
Connectivity	70
Notes	Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
Hugo ID	8979


Alias	LOC153387
	Phosphatidylinositol 3-kinase, regulatory, 1
	p85-ALPHA
	GRB1
	expressed sequence AA414921
	Phosphatidylinositol 3-kinase, regulatory, I
	AA414921
	3-phosphatidylinositol kinase 85K chain
	Pik3r1
	p50alpha
	p55alpha
	Pik3r I
	GRB I
	P(85)A
	P-85A
	P85-A
	P 85A
	P85A
	Phosphoinositide 3-kinase p85
	C530050K14
	phosphatidylinositol 3-kinase-associated p-85 alpha
	p85alpha regulatory subunit of phosphoinositide 3-kinase
	phosphoinositide 3-kinase, regulatory subunit, polypeptide 1
	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide I
	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1
	phosphoinositide 3-kinase, regulatory subunit, polypeptide I
	Phosphatidylinositol 3-kinase regulatory alpha subunit
	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha
	phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
	PI3KA
	PI3-kinase P85- alpha subunit
	PtdIns-3-kinase P85-alpha
	hypothetical gene supported by AK049798
	P85A_HUMAN
	Phosphatidylinositol 3-kinase, regulatory


FunctionalClass	phosphatidylinositol 3-kinase
	phosphatidylinositol binding
	kinase
	protein binding


RGD ID	3329


Hugo Symbol	PIK3R1


GO Cellular Component	cellular component unknown
	phosphoinositide 3-kinase complex


Cell Localization	Cytoplasm


Pathway	TLR2 -> MHC2TA signalling pathway
	CSF1-IL6R
	CSF1-TNFRSF5
	DTR-EGFR
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	GRO1-EGFR
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	IL10-TNFRSF7
	IL3-EPOR
	INS-EGFR
	INS-HLA-DRB1
	INS-TFRC
	THPO-EPOR
	VEGF-EGFR
	AR
	ERalpha
	GR
	Donna's proteomics


GO Biological Process	B-cell differentiation
	intracellular signaling cascade
	B cell differentiation
	negative regulation of apoptosis
	protein amino acid phosphorylation


Group	Sh2


State	phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 2
	phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 1
	phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 isoform 3


State Description	Transcript Variant: This variant (1) encodes the longest isoform (1) of this protein.
	Transcript Variant: This variant (2) uses an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus, compared to isoform 1.
	Transcript Variant: This variant (3) uses an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus, compared to isoform 1.


MGI ID	97583


Swiss-Prot Accession	P27986


OMIM ID	171833


Source	Curated