| Name | IPO7 |
|---|---|
| Description | importin 7 |
| Owner | Public |
| URN | urn:agi-llid:10527 |
| Connectivity | 2 |
| Notes | The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. Similar to importin-beta, this protein prevents the activation of Ran's GTPase by RanGAP1 and inhibits nucleotide exchange on RanGTP, and also binds directly to nuclear pore complexes where it competes for binding sites with importin-beta and transportin. This protein has a Ran-dependent transport cycle and it can cross the nuclear envelope rapidly and in both directions. At least four importin beta-like transport receptors, namely importin beta itself, transportin, RanBP5 and RanBP7, directly bind and import ribosomal proteins. Nuclear import of HIV-1 intracellular reverse transcription is mediated by IPO7. Role of IMP7 in nuclear transport of H1 histones. |
| Microarray ID | 1380578_at |
|---|---|
| rc_aa859349_at | |
| A_52_P239403 | |
| AF098799 | |
| 200992_at | |
| 200993_at | |
| 200994_at | |
| 200995_at | |
| 35255_at | |
| 47570_at | |
| C02472_at | |
| A_32_P139588 | |
| A_23_P331598 | |
| A_14_P132263 | |
| A_14_P105627 | |
| A_14_P112469 | |
| A_32_P186226 | |
| OH4827 |
| Chromosome position | 11p15.4 |
|---|---|
| 7 E3 | |
| 1q33 |
| GO ID | 0000059 |
|---|---|
| 0005083 | |
| 0005488 | |
| 0005625 | |
| 0005634 | |
| 0005643 | |
| 0005737 | |
| 0007165 | |
| 0008536 | |
| 0008565 | |
| 0015031 | |
| 0042393 | |
| 0005515 | |
| 0006606 | |
| 0006810 |
| Alias | RAN binding protein 7 |
|---|---|
| RIKEN cDNA A330055O14 gene | |
| RAN binding protein 7 (importin 7) | |
| C330016G14 | |
| RAN binding protein VII | |
| Imp7 | |
| RANBP7 | |
| IPO7 | |
| importin VII | |
| RANBP7s | |
| RanBP7/importin VII | |
| A330055O14Rik | |
| importin 7 | |
| RanBP7/importin 7 |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Homo sapiens |
| MedLine Reference | 9214382 |
|---|---|
| 10891500 | |
| 11493596 |
| LocusLink ID | 10527 |
|---|---|
| 233726 | |
| 117213 | |
| 308939 |
| FunctionalClass | Ran GTPase binding |
|---|---|
| binding | |
| protein transporter | |
| small GTPase regulator | |
| histone binding | |
| protein binding |
| GO Cellular Component | cytoplasm |
|---|---|
| nuclear pore | |
| nucleus | |
| soluble fraction |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | GR |
|---|
| GO Biological Process | protein transport |
|---|---|
| protein-nucleus import, docking | |
| signal transduction | |
| protein-nucleus import | |
| transport |
| Group | Gtp binding proteins |
|---|
| Source | Curated |
|---|