| Name | JARID1A |
|---|---|
| Description | Jumonji, AT rich interactive domain 1A (RBBP2-like) |
| Owner | Public |
| URN | urn:agi-llid:5927 |
| Connectivity | 6 |
| Notes | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein which regulates cell proliferation. This protein also interacts with rhombotin-2 which functions distinctly in erythropoiesis and in T-cell leukemogenesis. Rhombotin-2 is thought to either directly affect the activity of the encoded protein or may indirectly modulate the functions of the retinoblastoma protein by binding to this protein. |
| Microarray ID | A_51_P258381 |
|---|---|
| A_51_P399143 | |
| A_52_P125363 | |
| A_65_P10910 | |
| A_65_P10506 | |
| A_65_P20630 | |
| 36999_at | |
| 202040_s_at | |
| 215698_at | |
| 226367_at | |
| 226371_at | |
| 230226_s_at | |
| 1785_at | |
| S66431_at | |
| 50532_at | |
| rc_aa487492_s_at | |
| A_23_P204406 | |
| A_14_P114619 | |
| A_14_P117475 | |
| A_23_P204408 | |
| C51 | |
| OH2732 |
| Chromosome position | 6 F1 |
|---|---|
| 12p11 | |
| 4q42 |
| GO ID | 0003677 |
|---|---|
| 0005622 | |
| 0003700 | |
| 0005515 | |
| 0005634 | |
| 0006350 | |
| 0006355 | |
| 0006366 | |
| 0008270 | |
| 0016563 | |
| 0045941 | |
| 0046872 |
| Alias | retinoblastoma binding protein 2 |
|---|---|
| MGC11659 | |
| RBB2 | |
| RBBP2 | |
| C76986 | |
| RBB2_HUMAN | |
| AA409370 | |
| expressed sequence AA409370 | |
| retinoblastoma binding protein II | |
| EST C76986 | |
| Retinoblastoma-binding protein 2 (RBBP-2) | |
| hypothetical protein MGC11659 | |
| jumonji, at rich interactive domain 1a | |
| C76986s | |
| JARID1A | |
| Jumonji, AT rich interactive domain 1A (RBP2-like) |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Homo sapiens |
| MedLine Reference | 11358960 |
|---|---|
| 1857421 | |
| 8414517 | |
| 12466851 |
| LocusLink ID | 214899 |
|---|---|
| 30852 | |
| 94042 | |
| 101046 | |
| 297563 | |
| 5927 |
| FunctionalClass | DNA binding |
|---|---|
| metal ion binding | |
| protein binding | |
| transcription factor | |
| transcriptional activator | |
| zinc ion binding |
| GO Cellular Component | intracellular |
|---|---|
| nucleus |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | ERalpha |
|---|---|
| GR |
| GO Biological Process | positive regulation of transcription |
|---|---|
| regulation of transcription, DNA-dependent | |
| transcription | |
| transcription from RNA polymerase II promoter |
| Group | Transcription factors |
|---|
| Source | Curated |
|---|