| Name | NFKBIA |
|---|---|
| Description | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| Owner | Public |
| URN | urn:agi-llid:4792 |
| Connectivity | 132 |
| Notes | Inhibits NFkB activity by binding the rel domains of NF-kB components; contains ankyrin repeats |
| Hugo ID | 7797 |
| Microarray ID | X63594cds_at |
|---|---|
| 133630_r_at | |
| 1438157_s_at | |
| 1448306_at | |
| 167965_f_at | |
| msa.1690.0_at | |
| msa.1690.0_g_at | |
| A_51_P295192 | |
| 201502_s_at | |
| 231699_at | |
| 1461_at | |
| M69043_at | |
| A_23_P106002 | |
| A_14_P120088 | |
| A_14_P114684 | |
| A_14_P133399 | |
| M461 | |
| R576 | |
| OR0744B | |
| CA169 | |
| OH5877 | |
| A_42_P544487 | |
| 101554_at | |
| X63594cds_g_at | |
| 206329_Rn | |
| A_65_P03979 | |
| H3026A08-3 | |
| NM_010907 | |
| I_959455 |
| Chromosome position | 6q23 |
|---|---|
| 14q13 | |
| 12 C1-C3 |
| GO ID | 0000060 |
|---|---|
| 0005515 | |
| 0005634 | |
| 0005829 | |
| 0042127 | |
| 0045638 | |
| 0045746 | |
| 0005737 | |
| 0006915 | |
| 0007253 | |
| 0008134 | |
| 0009618 | |
| GO:0005515 | |
| GO:0000060 | |
| GO:0042127 | |
| GO:0005829 | |
| GO:0005737 | |
| GO:0005634 | |
| GO:0008134 | |
| GO:0007253 | |
| GO:0009618 | |
| GO:0006915 | |
| GO:0003719 |
| Alias | Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha |
|---|---|
| I(Kappa)B(alpha) | |
| I-kappaB-alpha | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | |
| MAD III | |
| I-kappa-B-alpha | |
| IKB-alpha | |
| MAD-III | |
| MAD-3 | |
| RL/IF-1 | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibito | |
| IkappaBalpha | |
| IKBA | |
| IkBalpha | |
| major histocompatibility complex enhance-binding protein MAD3 | |
| Major histocompatibility complex enhancer- binding protein MAD3 | |
| Nfkbia | |
| RL/IF I | |
| lkappa-Balpha | |
| Nuclear factor of kappa light chain gene enhancer in B-cells | |
| AI462015 | |
| NF-kappaB inhibitor alpha | |
| nuclear factor of kappa light polyp gene enhancer in B-cell 1 | |
| nuclear factor of kappa light polyp gene enhancer in B-cell I | |
| Inhibitor of 3000097 | |
| NFKBI | |
| IKBA_HUMAN | |
| P-I-kappaB-alpha | |
| expressed sequence AI462015 | |
| MAD-3/I kappa B alpha | |
| RL/IF Is | |
| RL/IF-1s | |
| IkappaB-alpha/MAD3 | |
| IkappaB/MAD3 | |
| nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha | |
| Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha |
| Organism | Human |
|---|---|
| Rattus norvegicus | |
| Mus musculus | |
| Homo sapiens |
| MedLine Reference | 11799106 |
|---|---|
| 15845452 | |
| 10747850 | |
| 10928981 | |
| 9865694 |
| LocusLink ID | 104829 |
|---|---|
| 4792 | |
| 25493 | |
| 18035 |
| FunctionalClass | protein binding |
|---|---|
| transcription factor binding |
| RGD ID | 3171 |
|---|
| Hugo Symbol | NFKBIA |
|---|
| Unigene ID | Rn.12550 |
|---|---|
| Mm.170515 | |
| Hs.81328 | |
| Rn.104476 |
| Keyword | cytoplasm |
|---|---|
| ubiquitin | |
| nucleus | |
| DNA | |
| binding activity | |
| kinetochore |
| GO Cellular Component | cytosol |
|---|---|
| nucleus | |
| cytoplasm |
| GO Molecular Function | protein binding |
|---|---|
| transcription factor binding | |
| transcription factor binding, cytoplasmic sequestering | |
| transcription factor, cytoplasmic sequestering |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | NF kappa B |
|---|---|
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| F2-ITGAV | |
| F2-LRP1 | |
| F2-LRP2 | |
| F2-THBD | |
| FGF2-CD44 | |
| FGF2-FGFR2 | |
| FGF2-FGFR3 | |
| FGF2-GPC1 | |
| FGF2-TGFBR3 | |
| IFNB1-IFNAR1 | |
| IFNB1-IFNAR2 | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| IGF2-IGF2R | |
| IL10-TNFRSF7 | |
| IL1A-IL1RAP | |
| IL1B-HLA-DRB1 | |
| IL1B-IL1R1 | |
| IL1B-IL1RAP | |
| IL1B-IL6R | |
| IL4-FCER2 | |
| IL6-IL6R | |
| IL6-LIFR | |
| INHBA-ACVR1B | |
| INHBA-ACVR2B | |
| INHBA-ACVRL1 | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-TFRC | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| NPPA-NPTXR | |
| NRG1-CD44 | |
| NRG1-ERBB2 | |
| NRG1-ERBB3 | |
| NRG1-ERBB4 | |
| OSM-CD22 | |
| OSM-LIFR | |
| PGF-FLT1 | |
| PGF-KDR | |
| SPP1-CD44 | |
| SPP1-ITGAV | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1B | |
| TNFSF10-TNFRSF1A | |
| TNFSF11-TNFRSF11A | |
| TNFSF11-TNFRSF11B | |
| TNFSF7-CD28 | |
| PPAR all | |
| PPARalpha | |
| GR | |
| NR common targets |
| Compartment | cytoplasm |
|---|---|
| DNA | |
| void |
| GO Biological Process | apoptosis |
|---|---|
| negative regulation of Notch signaling pathway | |
| negative regulation of myeloid cell differentiation | |
| protein-nucleus import, translocation | |
| regulation of cell proliferation | |
| cytoplasmic sequestering of NF-kappaB | |
| response to pathogenic bacteria |
| Proteome Organismal Role | Cell death/Apoptosis |
|---|---|
| Anti-pathogen response |
| RefSeq ACCNUM | NP_065390 |
|---|
| Proteome Subcellular Localization | Cytoplasmic |
|---|
| Proteome Biochemical Function | Inhibitor or repressor |
|---|
| MGI ID | 104741 |
|---|
| Swiss-Prot Accession | P25963 |
|---|
| OMIM ID | 164008 |
|---|---|
| OMIM:164008 |
| Source | BIND |
|---|---|
| ResNet | |
| Curated |