| Name | PPARGC1 |
|---|---|
| Description | peroxisome proliferative activated receptor, gamma, coactivator 1, alpha |
| Owner | Public |
| URN | urn:agi-llid:10891 |
| Connectivity | 58 |
| Notes | The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. |
| Hugo ID | 9237 |
| Microarray ID | 1370089_at |
|---|---|
| A_43_P12562 | |
| 102240_at | |
| 1460336_at | |
| A_51_P279038 | |
| 47588_at | |
| 81839_at | |
| 91360_at | |
| 219195_at | |
| 1569141_a_at | |
| rc_d59328_at | |
| rc_n89673_f_at | |
| A_23_P18443 | |
| A_14_P131160 | |
| A_14_P138089 | |
| A_14_P132974 | |
| A_23_P18447 | |
| A_24_P303052 | |
| OH5560 | |
| OR1929 |
| Chromosome position | 5 C1 |
|---|---|
| 4p15.1 | |
| 14q11 |
| GO ID | 0000166 |
|---|---|
| 0001659 | |
| 0001678 | |
| 0003677 | |
| 0003723 | |
| 0005634 | |
| 0005665 | |
| 0006094 | |
| 0006350 | |
| 0006367 | |
| 0006397 | |
| 0006461 | |
| 0007005 | |
| 0007586 | |
| 0008134 | |
| 0008380 | |
| 0016455 | |
| 0019395 | |
| 0030374 | |
| 0030521 | |
| 0035066 | |
| 0042594 | |
| 0045333 | |
| 0045722 | |
| 0045893 | |
| 0046321 | |
| 0050681 | |
| 0050821 | |
| 0050873 | |
| 0003676 | |
| 0003713 | |
| 0005515 | |
| 0006118 | |
| 0006355 | |
| 0016563 | |
| 0045941 |
| Alias | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha |
|---|---|
| LEM6 | |
| PGC-1(alpha) | |
| PPARGC1A | |
| Pgc-1alphaa | |
| ligand effect modulator VI | |
| ligand effect modulator-6 | |
| RIKEN cDNA A830037N07 gene | |
| peroxisome proliferative activated receptor, gamma, coactivator 1 | |
| Pgco1 | |
| PPAR gamma coactivator-1 | |
| Ppargc1 | |
| A830037N07Rik | |
| PGC1A | |
| peroxisome proliferative activated receptor, gamma, coactivator I | |
| PGC1 | |
| PGC I | |
| Pgco I | |
| Ppargc I | |
| PPAR gamma coactivator I | |
| peroxisome proliferative activated receptor, gamma, coactivator |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MedLine Reference | 10585775 |
|---|---|
| 10713165 | |
| 11551810 | |
| 11854298 | |
| 1258810 | |
| 12588810 | |
| 14636573 | |
| 15572661 | |
| 12107181 | |
| 12466851 | |
| 14744933 | |
| 15681609 | |
| 9529258 |
| LocusLink ID | 10891 |
|---|---|
| 83516 | |
| 320239 | |
| 19017 |
| FunctionalClass | nucleotide binding |
|---|---|
| transcription factor binding | |
| nucleic acid binding | |
| protein binding | |
| transcription coactivator | |
| transcriptional activator | |
| DNA binding | |
| RNA binding | |
| RNA polymerase II transcription mediator | |
| androgen receptor binding | |
| ligand-dependent nuclear receptor transcription coactivator |
| RGD ID | 620925 |
|---|
| Hugo Symbol | PPARGC1A |
|---|
| Unigene ID | Rn.19172 |
|---|---|
| Hs.527078 | |
| Mm.347722 |
| GO Cellular Component | DNA-directed RNA polymerase II, core complex |
|---|---|
| nucleus |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | INS-EGFR |
|---|---|
| INS-HLA-DRB1 | |
| INS-TFRC | |
| Volcano 2 | |
| PXR | |
| PPAR all | |
| PPARgamma | |
| FXR | |
| PPARalpha | |
| PGC1alpha | |
| LXR | |
| RXR | |
| ERalpha | |
| GR | |
| MR | |
| HNF4a | |
| TR | |
| NR common targets | |
| NR common regulators | |
| PPARalpha large | |
| Donna's proteomics |
| GO Biological Process | brown adipocyte differentiation |
|---|---|
| transcription initiation from Pol II promoter | |
| RNA splicing | |
| androgen receptor signaling pathway | |
| brown fat cell differentiation | |
| cell glucose homeostasis | |
| cellular respiration | |
| digestion | |
| fatty acid oxidation | |
| gluconeogenesis | |
| mRNA processing | |
| mitochondrion organization and biogenesis | |
| positive regulation of fatty acid oxidation | |
| positive regulation of gluconeogenesis | |
| positive regulation of histone acetylation | |
| positive regulation of transcription, DNA-dependent | |
| protein complex assembly | |
| protein stabilization | |
| response to starvation | |
| thermoregulation | |
| transcription | |
| transcription initiation from RNA polymerase II promoter | |
| electron transport | |
| positive regulation of transcription | |
| regulation of transcription, DNA-dependent |
| Group | Transcription factors |
|---|
| MGI ID | 1342774 |
|---|
| Swiss-Prot Accession | Q9UBK2 |
|---|
| OMIM ID | 604517 |
|---|
| Source | Curated |
|---|