| Name | ETS2 |
|---|---|
| Description | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) |
| Owner | Public |
| URN | urn:agi-llid:2114 |
| Connectivity | 47 |
| Notes | Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer. ETS2 is a target of protein kinase C and upregulates GM-CSF. Ets-2 and its targets play essential roles in endothelial cell function. Linkage of elevated expression to hepatocarcinogenesis. Overexpression of ETS2 in human esophageal squamous cell carcinoma in both mRNA and protein levels. Phosphorylated ERK1/2 was further associated with the presence of VEGFR2 (cohorts II and III) and the degree of phosphorylated Ets-2, indicating in vivo, a signalling cascade from VEGFR2 via ERK1/2 to Ets-2 phosphorylation. Ras/mitogen-activated kinase signaling activates ETS2 by CBP/p300 recruitment. Two closely spaced Ets-2 binding sites in the proximal promoter of the human chorionic gonadotropin beta5 (hCGbeta5) gene constitute a major enhancer for hCGbeta gene expression in JAr and JEG-3 human choriocarcinoma cells and in mouse NIH3T3 cells. Analysis of Ets2 in cell-seeded three-dimensional bone constructs. Ets-2 has a role as a repressor and indicate that components of the mammalian SNF/SWI complex are required as co-repressors. |
| Hugo ID | 3489 |
| Microarray ID | msa.626.0_at |
|---|---|
| msa.626.0_g_at | |
| A_51_P332797 | |
| A_65_P04953 | |
| J04102 | |
| 201329_s_at | |
| 222303_at | |
| 201328_at | |
| 241193_at | |
| 242784_at | |
| 1519_at | |
| 38739_at | |
| j04102_at | |
| A_23_P257924 | |
| A_14_P117113 | |
| A_14_P118068 | |
| A_14_P105020 | |
| A_24_P314179 | |
| A_24_P382661 | |
| E241 | |
| OH8484 | |
| M338 |
| Chromosome position | 16 69.6 cM |
|---|---|
| 21q22.3 | |
| 11q11 |
| GO ID | 0016563 |
|---|---|
| 0035259 | |
| 0045943 | |
| 0001501 | |
| 0003700 | |
| 0005634 | |
| 0006355 | |
| 0000074 | |
| 0003677 | |
| 0005622 | |
| 0050875 |
| Alias | v-ets avian erythroblastosis virus E2 oncogene homolog 2 |
|---|---|
| Oncogene ETS II | |
| C-ets-2 proteins | |
| avian erythroblastosis virus e26 (v-ets) oncogene homolog 2 | |
| avian erythroblastosis virus e26 (v-ets) oncogene homolog II | |
| C-ets-2 protein | |
| E26 avian leukemia oncogene 2, 3' domain | |
| Ets2 | |
| human erythroblastosis virus oncogene homolog 2 | |
| Oncogene ETS-2 | |
| v-ets avian erythroblastosis virus E26 oncogene homolog 2 | |
| v-ets erythroblastosis virus E26 oncogene homolog 2 | |
| v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) | |
| LOC304063 | |
| human erythroblastosis virus oncogene homolog II | |
| v-ets erythroblastosis virus E26 oncogene homolog II | |
| v-ets avian erythroblastosis virus E2 oncogene homolog II | |
| v-ets avian erythroblastosis virus E26 oncogene homolog II |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 8596630 |
|---|---|
| 11279115 |
| LocusLink ID | 304063 |
|---|---|
| 24357 | |
| 2114 | |
| 106340 | |
| 23872 |
| FunctionalClass | transcription factor |
|---|---|
| glucocorticoid receptor binding | |
| transcriptional activator | |
| DNA binding |
| RGD ID | 2584 |
|---|
| Hugo Symbol | ETS2 |
|---|
| Unigene ID | Mm.290207 |
|---|---|
| Hs.517296 | |
| Rn.32206 |
| GO Cellular Component | nucleus |
|---|---|
| intracellular |
| Cell Localization | Nucleus |
|---|
| Pathway | ERBB2 -> ETS2 signalling pathway |
|---|---|
| CSF1-CSF1R | |
| CSF1-IL6R | |
| CSF1-TNFRSF5 | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-TFRC | |
| GR |
| GO Biological Process | positive regulation of transcription from Pol I promoter |
|---|---|
| regulation of cell cycle | |
| regulation of transcription, DNA-dependent | |
| skeletal development | |
| positive regulation of transcription from RNA polymerase I promoter | |
| cellular physiological process | |
| regulation of progression through cell cycle |
| Group | Transcription factors |
|---|
| MGI ID | 95456 |
|---|
| Swiss-Prot Accession | P15036 |
|---|
| OMIM ID | 164740 |
|---|
| Source | Curated |
|---|