| Name | CREB1 |
|---|---|
| Description | cAMP responsive element binding protein 1 |
| Owner | Public |
| URN | urn:agi-llid:1385 |
| Connectivity | 301 |
| Notes | This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. |
| Hugo ID | 2345 |
| Microarray ID | 102673_at |
|---|---|
| 1369708_a_at | |
| x14788_s_at | |
| 102671_at | |
| 102672_g_at | |
| 129390_f_at | |
| 135215_at | |
| 139971_f_at | |
| 1421582_a_at | |
| 1423402_at | |
| 1452529_a_at | |
| 167083_f_at | |
| 169750_at | |
| msa.552.0_s_at | |
| x92497_s_at | |
| A_51_P472638 | |
| M34356 | |
| 204313_s_at | |
| 204312_x_at | |
| 214513_s_at | |
| 37535_at | |
| 204314_s_at | |
| 225565_at | |
| 225572_at | |
| 237289_at | |
| 877_at | |
| M27691_at | |
| X60003_s_at | |
| rc_n74123_s_at | |
| s78693_f_at | |
| A_14_P115929 | |
| A_14_P124680 | |
| A_14_P121644 | |
| A_14_P139324 | |
| A_14_P128822 | |
| A_23_P79231 | |
| A_24_P105721 | |
| A_24_P932208 | |
| 427 | |
| OH0968 | |
| R557 | |
| OR0727 | |
| MA077 | |
| 1421583_at | |
| 129391_r_at | |
| NM_009952 | |
| 65541_at | |
| 90568_at | |
| RC_AA504144_at | |
| I_928618 |
| Chromosome position | 2q34 |
|---|---|
| 1 31.0 cM | |
| 9q32 |
| GO ID | GO:0045182 |
|---|---|
| GO:0005515 | |
| GO:0003677 | |
| GO:0003700 | |
| GO:0006355 | |
| GO:0005634 | |
| GO:0007409 | |
| GO:0008361 | |
| GO:0005667 | |
| GO:0003712 | |
| GO:0007165 | |
| 0003677 | |
| 0005667 | |
| 0006350 | |
| 0007409 | |
| 0008361 | |
| 0003705 | |
| 0005739 | |
| 0042752 | |
| 0042981 | |
| 0045944 | |
| 0003700 | |
| 0003712 | |
| 0005515 | |
| 0005634 | |
| 0006355 | |
| 0007165 |
| Alias | Creb1 |
|---|---|
| cAMP response element binding protein 1 | |
| Creb-1 | |
| transactivator protein | |
| Creb | |
| (CREB) | |
| 2310001E10Rik | |
| active transcription factor CREB | |
| cAMP responsive element binding protein 1 | |
| cAMP-response element binding protein | |
| MGC9284 | |
| cAMP responsive element binding protein I | |
| cAMP-response element-binding protein I | |
| cAMP-response element-binding protein-1 | |
| Creb I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Human |
| MedLine Reference | 12409294 |
|---|---|
| 12939230 | |
| 11354513 | |
| 11988169 | |
| 12015964 | |
| 12220541 | |
| 14594818 | |
| 7565774 | |
| 10909971 | |
| 14506290 | |
| 2974179 | |
| 8552098 |
| LocusLink ID | 81646 |
|---|---|
| 1385 | |
| 98624 | |
| 66351 | |
| 12912 |
| FunctionalClass | DNA binding |
|---|---|
| RNA polymerase II transcription factor activity, enhancer binding | |
| protein binding | |
| transcription cofactor | |
| transcription factor |
| RGD ID | 620218 |
|---|
| Hugo Symbol | CREB1 |
|---|
| Unigene ID | Rn.90061 |
|---|---|
| Mm.370176 | |
| Hs.549028 | |
| Mm.1376 | |
| Hs.22315 | |
| Hs.79194 | |
| Hs.516646 |
| Keyword | transcription activating factor |
|---|---|
| transcription factor | |
| nucleus | |
| cAMP-dependent protein kinase | |
| bzip transcription factor | |
| growth factor | |
| retinoid-X receptor | |
| transcription coactivator |
| GO Cellular Component | nucleus |
|---|---|
| transcription factor complex | |
| mitochondrion |
| GO Molecular Function | protein binding |
|---|---|
| DNA binding | |
| transcription factor activity | |
| transcription cofactor activity | |
| protein binding activity | |
| DNA binding activity | |
| translation regulator activity |
| Cell Localization | Nucleus |
|---|
| Pathway | p38 MAPK |
|---|---|
| p40 MAPK | |
| CREB signaling | |
| p38 Signaling | |
| NCAM1 -> CREB1 signalling pathway | |
| NGFR -> CREB1 signalling pathway | |
| NTRK1 -> CREB1 signalling pathway | |
| NTRK2 -> CREB1 signalling pathway | |
| OPRD1 -> CREB1 signalling pathway | |
| TNFRSF1A -> CREB1 signalling pathway | |
| TNFRSF1B -> CREB1 signalling pathway | |
| ADRB2 -> CREB1 signalling pathway | |
| AGER -> CREB1 signalling pathway | |
| AGTR1 -> CREB1 signalling pathway | |
| AGTR2 -> CREB1 signalling pathway | |
| VIPR1 -> CREB1 signalling pathway | |
| ICAM1 -> CREB1 signalling pathway | |
| TNFRSF6 -> CREB1 signalling pathway | |
| KDR -> CREB1 signalling pathway | |
| CD28 -> CREB1 signalling pathway | |
| TNFRSF5 -> CREB1 signalling pathway | |
| F2R -> CREB1 signalling pathway | |
| FGFR1 -> CREB1 signalling pathway | |
| FLT1 -> CREB1 signalling pathway | |
| TACR1 -> CREB1 signalling pathway | |
| TBXA2R -> CREB1 signalling pathway | |
| GRIN1 -> CREB1 signalling pathway | |
| GRM1 -> CREB1 signalling pathway | |
| GRM5 -> CREB1 signalling pathway | |
| CHRNA7 -> CREB1 signalling pathway | |
| DRD1 -> CREB1 signalling pathway | |
| DRD2 -> CREB1 signalling pathway | |
| RET -> CREB1 signalling pathway | |
| EDNRA -> CREB1 signalling pathway | |
| EDNRB -> CREB1 signalling pathway | |
| EGFR -> CREB1 signalling pathway | |
| AGT-LRP2 | |
| BDNF-NCAM1 | |
| BDNF-NGFR | |
| BDNF-NTRK1 | |
| BDNF-NTRK2 | |
| BDNF-NTRK3 | |
| BMP2-ACVR1 | |
| BMP2-ACVR2 | |
| BMP2-BMPR1A | |
| BMP2-BMPR1B | |
| BMP2-BMPR2 | |
| CSF2-CSF2RA | |
| EGF-EGFR | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| EPO-EPOR | |
| F2-ITGAV | |
| F2-LRP1 | |
| F2-LRP2 | |
| F2-THBD | |
| FGF2-CD44 | |
| FGF2-FGFR1 | |
| FGF2-FGFR2 | |
| FGF2-FGFR3 | |
| FGF2-GPC1 | |
| FGF2-TGFBR3 | |
| GDNF-RET | |
| GH1-GHR | |
| GH1-IGF1R | |
| GH1-PRLR | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF1R | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| IGF2-IGF1R | |
| IGF2-IGF2R | |
| IL10-IL10RA | |
| IL10-TNFRSF7 | |
| IL17-IL17R | |
| IL1A-IL1R1 | |
| IL1A-IL1RAP | |
| IL1B-HLA-DRB1 | |
| IL1B-IL1R1 | |
| IL1B-IL1RAP | |
| IL1B-IL6R | |
| IL2-IL15RA | |
| IL2-IL2RA | |
| IL2-IL2RB | |
| IL2-IL2RG | |
| IL2-IL4R | |
| IL3-CD8A | |
| IL3-CSF2RB2 | |
| IL3-EPOR | |
| IL3-IL3RA | |
| IL6-IL6R | |
| IL6-IL6ST | |
| IL6-LIFR | |
| IL6-TNFRSF5 | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-IGF1R | |
| INS-TFRC | |
| LEP-LEPR | |
| LEP-LRP2 | |
| LIF-IGF2R | |
| LIF-IL6ST | |
| LIF-LIFR | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| NRG1-CD44 | |
| NRG1-EGFR | |
| NRG1-ERBB2 | |
| NRG1-ERBB3 | |
| NRG1-ERBB4 | |
| NTF3-CNTFR | |
| NTF3-NGFR | |
| NTF3-NTRK1 | |
| NTF3-NTRK2 | |
| NTF3-NTRK3 | |
| NTF5-NGFR | |
| NTF5-NTRK1 | |
| NTF5-NTRK2 | |
| NTF5-NTRK3 | |
| OSM-CD22 | |
| OSM-IL6ST | |
| OSM-LIFR | |
| PTH-IL6ST | |
| SDF1-CD4 | |
| SDF1-IL6ST | |
| SELPLG-ICAM1 | |
| TAC1-TNFRSF11B | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| THPO-EPOR | |
| THPO-MPL | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1A | |
| TNF-TNFRSF1B | |
| TNF-TNFRSF6 | |
| TNFSF10-TNFRSF10A | |
| TNFSF10-TNFRSF10B | |
| TNFSF10-TNFRSF1A | |
| TNFSF10-TNFRSF6 | |
| TNFSF5-CD28 | |
| TNFSF5-CD80 | |
| TNFSF5-TNFRSF5 | |
| TNFSF5-TNFRSF6 | |
| TNFSF5-TNFRSF7 | |
| TNFSF5-TNFRSF8 | |
| VEGF-CD44 | |
| VEGF-EGFR | |
| VEGF-FLT1 | |
| VEGF-FLT4 | |
| VEGF-GPC1 | |
| VEGF-IL1R1 | |
| VEGF-KDR | |
| VEGFC-FLT1 | |
| VEGFC-FLT4 | |
| VEGFC-KDR | |
| Ben Common regulators | |
| PPAR all | |
| PPARgamma | |
| PGC1alpha | |
| AR | |
| ERalpha | |
| GR | |
| NOR1 | |
| Nurr1 | |
| Donna's proteomics |
| GO Biological Process | regulation of transcription, DNA-dependent |
|---|---|
| signal transduction | |
| axonogenesis | |
| regulation of cell size | |
| transcription | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of apoptosis | |
| regulation of circadian rhythm | |
| positive regulation of transcription from Pol II promoter |
| Group | Transcription factors |
|---|
| State | isoform B |
|---|---|
| isoform A | |
| p |
| State Description | Transcript Variant: This variant (A) lacks an in-frame exon in the coding region, compared to variant B. Isoform A is shorter compared to isoform B. |
|---|---|
| Transcript Variant: This variant (B) encodes the longer isoform (B) of this protein. |
| MGI ID | 88494 |
|---|
| Swiss-Prot Accession | P16220 |
|---|
| OMIM ID | 123810 |
|---|---|
| OMIM:123810 |
| Source | Curated |
|---|---|
| BIND | |
| ResNet |