| Name | EP300 |
|---|---|
| Description | E1A binding protein p300 |
| Owner | Public |
| URN | urn:agi-llid:2033 |
| Connectivity | 448 |
| Notes | EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CPB (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CPB can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. |
| Hugo ID | 3373 |
| Microarray ID | A_51_P142128 |
|---|---|
| A_51_P304029 | |
| 213579_s_at | |
| 33896_at | |
| 202221_s_at | |
| 551_at | |
| U01877_at | |
| rc_aa236852_s_at | |
| A_23_P40685 | |
| A_14_P108084 | |
| A_14_P127141 | |
| A_14_P124715 | |
| A_14_P119628 | |
| A_23_P40693 | |
| A_24_P7887 | |
| OH0886A |
| Chromosome position | 22q13.2 |
|---|---|
| 7q34 | |
| 15 E1 |
| GO ID | 0001666 |
|---|---|
| 0003700 | |
| 0003713 | |
| 0004402 | |
| 0005634 | |
| 0006355 | |
| 0006915 | |
| 0007049 | |
| 0007165 | |
| 0007399 | |
| 0008022 | |
| 0008270 | |
| 0016740 | |
| 0042592 | |
| 0046872 | |
| 0000123 | |
| 0003677 | |
| 0005515 | |
| 0005667 | |
| 0007507 | |
| 0007519 | |
| 0009887 | |
| 0016563 | |
| 0030324 | |
| 0045449 | |
| 0045893 | |
| 0006366 |
| Alias | E1A-binding protein, 300kD |
|---|---|
| p300/CBP | |
| CBP/p300 | |
| A430090G16 | |
| hypothetical protein A430090G16 | |
| otthump00000028668 | |
| 300 kDa E1A-binding protein | |
| 4930432K09Rik | |
| A730011L11 | |
| E1A binding protein p300 | |
| E1A-associated protein p300 | |
| EP300 | |
| hypothetical protein A730011L11 | |
| P300_HUMAN | |
| transcription adaptor p300 | |
| RIKEN cDNA 4930432K09 gene | |
| p300 | |
| transcription adaptor protein p300 |
| Organism | Human |
|---|---|
| Mus musculus | |
| Homo sapiens | |
| Rattus norvegicus |
| MedLine Reference | 10205054 |
|---|---|
| 10893273 | |
| 15261140 | |
| 9194565 | |
| 11567019 | |
| 11867645 | |
| 12464179 | |
| 14517255 | |
| 14517256 | |
| 15100295 | |
| 15681609 | |
| 9742083 |
| LocusLink ID | 2033 |
|---|---|
| 328572 | |
| 13816 | |
| 170915 | |
| 214392 |
| FunctionalClass | histone acetyltransferase |
|---|---|
| metal ion binding | |
| protein C-terminus binding | |
| transcription coactivator | |
| transcription factor | |
| transferase | |
| zinc ion binding | |
| DNA binding | |
| protein binding | |
| transcriptional activator |
| RGD ID | 620036 |
|---|
| Hugo Symbol | EP300 |
|---|
| Unigene ID | Hs.517517 |
|---|---|
| Rn.48331 | |
| Hs.271730 | |
| Rn.60218 | |
| Mm.258397 |
| GO Cellular Component | nucleus |
|---|---|
| histone acetyltransferase complex | |
| transcription factor complex |
| Cell Localization | Nucleus |
|---|
| Pathway | Control of skeletal myogenesis |
|---|---|
| TGF-beta signaling | |
| NOTCH1 -> EP300 signalling pathway | |
| ERBB2 -> EP300 signalling pathway | |
| CSF1-CSF1R | |
| CSF1-IL6R | |
| CSF1-TNFRSF5 | |
| F2-ITGAV | |
| F2-LRP1 | |
| F2-LRP2 | |
| F2-THBD | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IL4-FCER2 | |
| IL4-IL4R | |
| IL6-IL6R | |
| IL6-IL6ST | |
| IL6-LIFR | |
| IL6-TNFRSF5 | |
| NGFB-NGFR | |
| NGFB-NTRK1 | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1B | |
| DuPont 2 | |
| Volcano 2 | |
| CLADiff | |
| Ben Common regulators | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| PPARbeta | |
| LXR | |
| AR | |
| RXR | |
| ERalpha | |
| GR | |
| COUP-TF | |
| HNF4a | |
| NR common targets | |
| NR common regulators | |
| CITED2 | |
| DuPont 4 of 6 common regulators | |
| Donna's proteomics |
| GO Biological Process | transcription from Pol II promoter |
|---|---|
| apoptosis | |
| cell cycle | |
| homeostasis | |
| neurogenesis | |
| regulation of transcription, DNA-dependent | |
| response to hypoxia | |
| signal transduction | |
| heart development | |
| lung development | |
| myogenesis | |
| organogenesis | |
| positive regulation of transcription, DNA-dependent | |
| regulation of transcription |
| Group | Acetylases |
|---|---|
| Transcription factors |
| MGI ID | 1276116 |
|---|
| Swiss-Prot Accession | Q09472 |
|---|
| OMIM ID | OMIM:602700 |
|---|---|
| OMIM:114500 | |
| 602700 | |
| 114500 |
| Source | Curated |
|---|