| Name | BAG1 |
|---|---|
| Description | BCL2-associated athanogene |
| Owner | Public |
| URN | urn:agi-llid:573 |
| Connectivity | 31 |
| Notes | The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site. |
| Hugo ID | 937 |
| Microarray ID | OH8064 |
|---|---|
| MC199 | |
| 1375550_at | |
| rc_ai045819_at | |
| 101032_at | |
| 1416394_at | |
| 160540_at | |
| msa.1413.0_f_at | |
| u17162_f_at | |
| A_51_P224505 | |
| 34798_at | |
| 71009_at | |
| 202387_at | |
| 211475_s_at | |
| Z35491_at | |
| 75105_f_at | |
| 80600_s_at | |
| A_23_P146654 | |
| A_14_P136108 | |
| M437 | |
| C259 |
| Chromosome position | 4 B1 |
|---|---|
| 5q22 | |
| 9p12 |
| GO ID | 0005515 |
|---|---|
| 0005634 | |
| 0005829 | |
| 0030182 | |
| 0042981 | |
| 0005057 | |
| 0005737 | |
| 0006457 | |
| 0006464 | |
| 0006915 | |
| 0006916 | |
| 0007166 | |
| 0051082 |
| Alias | BCL2-associated athanogene I |
|---|---|
| Bag1_predicted | |
| similar to BAG-1 protein | |
| similar to BAG-1 - mouse | |
| hsp70/hsc70-associating protein | |
| BCL-2 binding athanogene-1 | |
| Bcl2-associated athanogene 1 isoform 1L | |
| BCL2-associated athanogene isoform 1L | |
| Rap46 | |
| BAG-1M | |
| HAP46 | |
| BAG-1Ms | |
| BAG1 | |
| BAG1_HUMAN | |
| BAG-family molecular chaperone regulator-1 | |
| BCL2-associated athanogene | |
| BCL2-associated athanogene 1 | |
| Glucocorticoid receptor-associated protein RAP46 | |
| BAG I | |
| BAG-family molecular chaperone regulator I | |
| BCL-2 binding athanogene I |
| Organism | Rattus norvegicus |
|---|---|
| Homo sapiens | |
| Mus musculus |
| MedLine Reference | 11965493 |
|---|---|
| 12819136 | |
| 8947043 |
| LocusLink ID | 12017 |
|---|---|
| 297994 | |
| 573 |
| FunctionalClass | protein binding |
|---|---|
| receptor signaling protein | |
| unfolded protein binding |
| RGD ID | 1305203 |
|---|
| Hugo Symbol | BAG1 |
|---|
| Unigene ID | Rn.16320 |
|---|---|
| Mm.688 | |
| Hs.377484 |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| nucleus |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | FGF2-GPC1 |
|---|---|
| FGF2-TGFBR3 | |
| HGF-MET | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IL2-IL15RA | |
| IL2-IL2RA | |
| IL2-IL2RB | |
| IL2-IL2RG | |
| IL2-IL4R | |
| IL4-FCER2 | |
| IL4-IL2RG | |
| IL4-IL4R | |
| AR | |
| GR | |
| NR common regulators |
| GO Biological Process | neuron cell differentiation |
|---|---|
| anti-apoptosis | |
| apoptosis | |
| cell surface receptor linked signal transduction | |
| protein folding | |
| protein modification | |
| neuron differentiation | |
| regulation of apoptosis |
| MGI ID | 108047 |
|---|
| Swiss-Prot Accession | Q99933 |
|---|
| OMIM ID | 601497 |
|---|
| Source | Curated |
|---|