| Name | CALR |
|---|---|
| Description | calreticulin |
| Owner | Public |
| URN | urn:agi-llid:811 |
| Connectivity | 70 |
| Notes | Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. |
| Hugo ID | 1455 |
| Microarray ID | d78308_at |
|---|---|
| d78308_g_at | |
| rc_ai030409_f_at | |
| x53363cds_s_at | |
| A_43_P12224 | |
| 1417606_a_at | |
| 1433806_x_at | |
| 1456170_x_at | |
| 93523_at | |
| x56603_s_at | |
| A_51_P416419 | |
| 212952_at | |
| 214316_x_at | |
| 214315_x_at | |
| 212953_x_at | |
| 32543_at | |
| 200935_at | |
| 1752_at | |
| M84739_at | |
| A_23_P67288 | |
| A_14_P107778 | |
| OR3011 | |
| S43 | |
| OH1436 | |
| A058 | |
| 1398750_at |
| Chromosome position | 19q11 |
|---|---|
| 19p13.3-p13.2 | |
| 8 37.0 cM |
| GO ID | 0005615 |
|---|---|
| 0005625 | |
| 0003677 | |
| 0005509 | |
| 0005529 | |
| 0005788 | |
| 0005829 | |
| 0006355 | |
| 0006457 | |
| 0006611 | |
| 0006874 | |
| 0051082 | |
| 0005783 | |
| 0009897 | |
| 0030866 | |
| 0040020 | |
| 0046872 |
| Alias | HACBP |
|---|---|
| CRTC_HUMAN | |
| RIKEN cDNA 4933403L16 gene | |
| Sicca syndrome antigen A (autoantigen Ro; ) | |
| Sicca syndrome antigen A (autoantigen Ro; calreticulin) | |
| CRT | |
| 52 kDa ribonuclear protein autoantigen RO/SS-A | |
| 52 kDa ribonucleoprotein autoantigen RO/SS-A | |
| CALR | |
| Sicca syndrome antigen A | |
| Calregulin | |
| CRP55 | |
| 4933403L16Rik | |
| autoantigen Ro | |
| calreticulin | |
| cC1qR | |
| CRTC |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MedLine Reference | 15136153 |
|---|---|
| 3513762 | |
| 12270713 | |
| 11149926 | |
| 8107808 |
| LocusLink ID | 12317 |
|---|---|
| 64202 | |
| 811 |
| FunctionalClass | metal ion binding |
|---|---|
| DNA binding | |
| calcium ion binding | |
| sugar binding | |
| unfolded protein binding |
| RGD ID | 620288 |
|---|
| Hugo Symbol | CALR |
|---|
| Unigene ID | Hs.515162 |
|---|---|
| Rn.974 | |
| Mm.1971 |
| GO Cellular Component | cytosol |
|---|---|
| endoplasmic reticulum lumen | |
| endoplasmic reticulum | |
| external side of plasma membrane | |
| extracellular space | |
| soluble fraction |
| Cell Localization | Endoplasmic reticulum |
|---|
| Pathway | AGT-LRP2 |
|---|---|
| CYR61-ITGAV | |
| F10-ITGAM | |
| F2-ITGAV | |
| F2-LRP1 | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IL4-FCER2 | |
| LPA-LDLR | |
| LPA-LRP2 | |
| NTN1-HLA-C | |
| PLG-LRP1 | |
| SCGB1A1-B2M | |
| AR | |
| GR | |
| COUP-TF | |
| DuPont 4 of 6 common targets | |
| DuPont 4 of 6 common regulators |
| GO Biological Process | calcium ion homeostasis |
|---|---|
| protein folding | |
| protein-nucleus export | |
| regulation of transcription, DNA-dependent | |
| cortical actin cytoskeleton organization and biogenesis | |
| regulation of meiosis |
| Group | duPont (4 of 6 FFA) |
|---|
| MGI ID | 88252 |
|---|
| Swiss-Prot Accession | P27797 |
|---|
| OMIM ID | 109091 |
|---|
| Source | Curated |
|---|