| Name | SMARCF1 |
|---|---|
| Description | AT rich interactive domain 1A (SWI- like) |
| Owner | Public |
| URN | urn:agi-llid:8289 |
| Connectivity | 4 |
| Notes | The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain which can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Three transcript variants encoding different isoforms have been found for this gene. ARID1B is associated with SWI/SNF-related complexes and indicates that ARID1A and ARID1B, similar to the ATPase subunits BRG1 and hBRM, are alternative, mutually exclusive subunits of the complexes. BAF250 chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner. SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1. Largest subunits of SWI/SNF participate in promoting transcriptional activation by the steroid hormone receptors. |
| Microarray ID | 1448709_at |
|---|---|
| aa260240_at | |
| A_51_P118671 | |
| 212152_x_at | |
| 35505_at | |
| 35504_at | |
| 61266_s_at | |
| 48675_at | |
| 72306_r_at | |
| 91080_at | |
| 218917_s_at | |
| 207591_s_at | |
| 210649_s_at | |
| 80675_at | |
| aa454070_at | |
| rc_aa458959_at | |
| A_23_P217879 | |
| A_14_P114927 | |
| A_14_P117107 | |
| A_14_P120735 | |
| A_23_P217872 | |
| A_24_P77219 | |
| A_24_P92952 | |
| OH3986 | |
| OH10329 | |
| AH0712 | |
| 104330_g_at | |
| 104331_at | |
| 1417440_at |
| Chromosome position | 4 D3 |
|---|---|
| 1p35.3 | |
| 5q36 |
| GO ID | 0005515 |
|---|---|
| 0016563 | |
| 0030520 | |
| 0030521 | |
| 0042766 | |
| 0048096 | |
| 0003677 | |
| 0005622 | |
| 0005634 | |
| 0006325 | |
| 0016514 |
| Alias | CG1368-PA |
|---|---|
| extensin-like protein - maize | |
| OSA1 nuclear protein | |
| chromosome 1 open reading frame IV | |
| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin f1 | |
| Osa I | |
| Smarcf I | |
| Osa1 | |
| similar to atrophin I | |
| 1110030E03Rik | |
| C10rf4 | |
| Brain protein 120 | |
| ARID1A | |
| AT rich interactive domain 1A (Swi1 like) | |
| AT rich interactive domain 1A (SWI- like) | |
| BAF250s | |
| at rich interactive domain 1a | |
| otthump00000044975 | |
| C1orf4 | |
| chromatin remodeling factor p250 | |
| chromosome 1 open reading frame 4 | |
| similar to atrophin-1 | |
| Smarcf1 | |
| SWI-SNF complex protein p270 | |
| B120 | |
| BAF250 | |
| BM029 | |
| BRG1-associated factor 250a |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 11318604 |
|---|---|
| 12466851 |
| LocusLink ID | 8289 |
|---|---|
| 55834 | |
| 93760 | |
| 68739 | |
| 297867 |
| FunctionalClass | protein binding |
|---|---|
| transcriptional activator | |
| DNA binding |
| GO Cellular Component | SWI/SNF complex |
|---|---|
| intracellular | |
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | GR |
|---|
| GO Biological Process | androgen receptor signaling pathway |
|---|---|
| chromatin-mediated maintenance of transcription | |
| estrogen receptor signaling pathway | |
| nucleosome mobilization | |
| establishment and/or maintenance of chromatin architecture |
| Group | Transcription factors |
|---|
| Source | Curated |
|---|