| Name | CRSP2 |
|---|---|
| Description | cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa |
| Owner | Public |
| URN | urn:agi-llid:9282 |
| Connectivity | 8 |
| Notes | The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation. CRSP2 gene is expressed in the retina and its exact genomic location is on Xp11.4 between DXS1368 and DXS993. Coactivation of ERalpha by DRIP150 in ZR-75 cells is NR box-independent and requires a novel sequence with putative alpha-helical structure. DRIP150 binds to ISGF3 and regulates transcription. |
| Microarray ID | 202612_s_at |
|---|---|
| 217120_s_at | |
| 1569449_a_at | |
| RC_AA460683_at | |
| rc_aa236017_at | |
| rc_r40567_at | |
| A_23_P72187 | |
| A_23_P21120 | |
| A_14_P132611 | |
| A_14_P139550 | |
| OH4189 | |
| 1450229_at | |
| 97796_at | |
| A_51_P164562 | |
| A_51_P281134 | |
| 202611_s_at | |
| 215167_at | |
| 231226_at | |
| 33344_at | |
| 82330_at | |
| 202610_s_at |
| Chromosome position | Xp11.4-p11.2 |
|---|---|
| X A1.1 |
| GO ID | 0000119 |
|---|---|
| 0004872 | |
| 0005634 | |
| 0006350 | |
| 0006357 | |
| 0006367 | |
| 0016455 | |
| 0016563 | |
| 0030374 | |
| 0030521 | |
| 0042809 | |
| 0046966 | |
| 0003713 | |
| 0045944 |
| Alias | thyroid hormone receptor-associated complex component TRAP170 |
|---|---|
| transcriptional co-activator CRSP150 | |
| AU041628 | |
| Lipogenin | |
| 2900053G10Rik | |
| DRIP150 | |
| TRAP170 | |
| EXLM I | |
| EXML I | |
| human homolog of RGR I | |
| RGR1 | |
| GM-641 | |
| GM(641) | |
| GM 641 | |
| GM641 | |
| cofactor required for Sp1 transcriptional activating subunit II | |
| RGR I | |
| Vitamin D receptor-interactive protein complex component DRIP150 | |
| expressed sequence AU041628 | |
| cofactor required for Sp1 transcriptional activation subunit II | |
| cofactor required for Sp1 transcriptional activation subunit 2 | |
| RIKEN cDNA 9930001L01 gene | |
| cofactor required for Sp1 transcriptional activating subunit 2 | |
| CXorf4 | |
| 9930001L01Rik | |
| CXorf4s | |
| cofactor required for sp1 transcriptional activation, subunit 2, 150kda | |
| mgc104513 | |
| med14 | |
| EXML1 | |
| human homolog of RGR1 | |
| Vitamin D receptor-interacting protein complex component DRIP150 | |
| 150kDa Sp1 cofactor | |
| chromosome X open reading frame 4 | |
| cofactor required for Sp1 transcriptional activation, subunit 2 (150kD) | |
| CRSP150 | |
| Crsp2 | |
| EXLM1 | |
| chromosome X open reading frame IV | |
| human homolog of yeast RGR1 | |
| Sp1 cofactor, 150kDa |
| Organism | Mus musculus |
|---|---|
| Homo sapiens |
| MedLine Reference | 10198638 |
|---|---|
| 10235266 | |
| 10235267 | |
| 12218053 | |
| 9989412 |
| LocusLink ID | 72974 |
|---|---|
| 9282 | |
| 26896 | |
| 102997 | |
| 270579 |
| FunctionalClass | RNA polymerase II transcription mediator |
|---|---|
| ligand-dependent nuclear receptor transcription coactivator | |
| receptor | |
| thyroid hormone receptor binding | |
| transcriptional activator | |
| vitamin D receptor binding | |
| transcription coactivator |
| GO Cellular Component | mediator complex |
|---|---|
| nucleus |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | GR |
|---|---|
| HNF4a |
| GO Biological Process | positive regulation of transcription from RNA polymerase II promoter |
|---|---|
| androgen receptor signaling pathway | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription | |
| transcription initiation from RNA polymerase II promoter |
| Group | Transcription factors |
|---|
| Source | Curated |
|---|