| Name | ONECUT1 |
|---|---|
| Description | one cut domain, family member 1 |
| Owner | Public |
| URN | urn:agi-llid:3175 |
| Connectivity | 21 |
| Notes | A comparision of gene expression patterns induced by hepatic nuclear factors, HNF6, HNF4alpha and HNF1beta, in a pancreatic beta-cell line. HNF6 has a role as a coactivator protein to potentiate the transcriptional activity of another liver factor, FoxA2. HNF6 protein stability is controlled by CBP acetylation. These findings define a precursor cellular stage of the embryonic pancreas and place Hnf1beta in a genetic hierarchy that regulates the generation of pancreatic endocrine cells. Identifed systematically the genes occupied by the transcriptional regulators HNF1alpha, HNF4alpha, and HNF6, together with RNA polymerase II in human liver and pancreatic islets. |
| Microarray ID | 1371034_at |
|---|---|
| 1387760_a_at | |
| y14933mrna_s_at | |
| A_43_P12284 | |
| 100737_at | |
| 1450252_at | |
| u95945_s_at | |
| A_51_P368894 | |
| A_51_P428977 | |
| 210745_at | |
| u77975_at | |
| A_32_P508044 | |
| A_23_P340717 | |
| A_14_P111778 | |
| OR3278A | |
| OH5948 | |
| RA1308 |
| Chromosome position | 15q21.1-q21.2 |
|---|---|
| 9 42.0 cM | |
| 8q24-q31 |
| GO ID | 0003700 |
|---|---|
| 0005634 | |
| 0006355 | |
| 0016563 | |
| 0003677 | |
| 0005667 | |
| 0006006 | |
| 0006350 | |
| 0007492 | |
| 0030154 |
| Alias | one cut domain, family member 1 |
|---|---|
| D9Ertd423e | |
| hepatocyte nuclear factor 6, alpha | |
| Hfh12 | |
| HNF-3/forkhead homolog 12 | |
| HNF6A | |
| similar to one cut domain, family member 3 | |
| Onecut1 | |
| Hepatocyte nuclear factor 6 | |
| Hepatocyte nuclear factor VI | |
| similar to one cut domain, family member III | |
| HNF-6 | |
| one cut domain, family member I | |
| Onecut I | |
| HNF VI |
| Organism | Mus musculus |
|---|---|
| Homo sapiens | |
| Rattus norvegicus |
| MedLine Reference | 15548585 |
|---|---|
| 10491763 | |
| 10825208 |
| LocusLink ID | 25231 |
|---|---|
| 110034 | |
| 15379 | |
| 15219 | |
| 52327 | |
| 3175 |
| FunctionalClass | transcription factor |
|---|---|
| transcriptional activator | |
| DNA binding |
| GO Cellular Component | transcription factor complex |
|---|---|
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | GR |
|---|---|
| HNF4a |
| GO Biological Process | cell differentiation |
|---|---|
| endoderm development | |
| glucose metabolism | |
| transcription | |
| regulation of transcription, DNA-dependent |
| Group | Transcription factors |
|---|
| Source | Curated |
|---|