| Name | SMARCE1 |
|---|---|
| Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 |
| Owner | Public |
| URN | urn:agi-llid:6605 |
| Connectivity | 8 |
| Notes | The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1. |
| Microarray ID | A_51_P435891 |
|---|---|
| 211988_at | |
| 211989_at | |
| 214871_x_at | |
| 229511_at | |
| 236016_at | |
| AA046548_at | |
| rc_aa599120_at | |
| A_32_P45410 | |
| A_32_P451285 | |
| A_23_P333060 | |
| A_23_P164387 | |
| A_14_P139112 | |
| A_23_P333063 | |
| OH3072 |
| Chromosome position | 17q21.2 |
|---|---|
| 11 D | |
| 6q21 |
| GO ID | 0000228 |
|---|---|
| 0003677 | |
| 0003682 | |
| 0003713 | |
| 0005515 | |
| 0006337 | |
| 0006357 | |
| 0008080 | |
| 0016568 | |
| 0017053 | |
| 0045892 | |
| 0005634 | |
| 0006355 |
| Alias | 2810417B20Rik |
|---|---|
| 9030408N19Rik | |
| BAF57 | |
| mammalian chromatin remodeling complex BRG1-associated factor 57 | |
| Smarce1 | |
| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1 | |
| Baf27 | |
| Smarce I |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 12192000 |
|---|---|
| 9435219 | |
| 12466851 |
| LocusLink ID | 69268 |
|---|---|
| 74535 | |
| 57376 | |
| 298972 | |
| 6605 |
| FunctionalClass | DNA binding |
|---|---|
| N-acetyltransferase | |
| chromatin binding | |
| protein binding | |
| transcription coactivator |
| GO Cellular Component | nuclear chromosome |
|---|---|
| transcriptional repressor complex | |
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | AR |
|---|---|
| ERalpha | |
| GR |
| GO Biological Process | chromatin modification |
|---|---|
| negative regulation of transcription, DNA-dependent | |
| nucleosome disassembly | |
| regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent |
| Group | Transcription factors |
|---|
| Source | Curated |
|---|