| Name | SMARCA2 |
|---|---|
| Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 |
| Owner | Public |
| URN | urn:agi-llid:6595 |
| Connectivity | 16 |
| Notes | The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. BRG1 and BRM complexes may direct distinct cellular processes by recruitment to specific promoters through protein-protein interactions that are unique to each ATPase. BRM and BRG1 participate in two distinct chromosome remodeling complexes that are functionally complementary in non-small cell lung cancer. Brm could also drive expression of CD44; Brm can compensate for BRG-1 loss as pertains to RB sensitivity. Brm-containing SWI/SNF complex subfamily (trithorax-G) and a complex including YY1 and HDACs (Polycomb-G) counteract each other to maintain transcription of exogenously introduced genes. Cell culture in the presence of HDAC inhibitors facilitates the isolation of clones overexpressing Brm. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2. This report provides supportive evidence that BRG1 and BRM act as tumor suppressor proteins and implicates a role for their loss in the development of non-small cell lung cancers. Human adrenal carcinoma cells can spontaneously transition between two subtypes by switching expression of BRG1 and Brm at the post-transcriptional level. |
| Microarray ID | 217707_x_at |
|---|---|
| 40962_s_at | |
| D26155_s_at | |
| N32716_at | |
| X72889_at | |
| A_14_P112263 | |
| A_14_P112573 | |
| A_14_P132731 | |
| A_14_P123409 | |
| A_23_P60354 | |
| A_23_P252765 | |
| A_23_P252764 | |
| 321 | |
| OH7505 | |
| O0005 | |
| 102384_at | |
| 1430526_a_at | |
| A_51_P450052 | |
| A_51_P504037 | |
| A_52_P388829 | |
| 212257_s_at | |
| 212258_s_at | |
| 206542_s_at | |
| 206543_at | |
| 228926_s_at | |
| 40961_at | |
| 206544_x_at |
| Chromosome position | 9p22.3 |
|---|---|
| 19 17.0 cM | |
| 1q51 |
| GO ID | 0000166 |
|---|---|
| 0003677 | |
| 0003713 | |
| 0004386 | |
| 0005524 | |
| 0005654 | |
| 0006350 | |
| 0006357 | |
| 0016787 | |
| 0042127 | |
| 0003676 | |
| 0005515 | |
| 0005634 | |
| 0006325 | |
| 0006334 | |
| 0006355 | |
| 0008285 | |
| 0016514 |
| Alias | 4933432C20 |
|---|---|
| BAF190 | |
| hBRM | |
| BAF190s | |
| subunit of the swi/snf chromatin remodeling complex | |
| flj36757 | |
| mgc74511 | |
| Possible global transcription activator SNF2L2 | |
| RIKEN cDNA 2610209L14 gene | |
| Smarca2 | |
| SNF2 (sucrose nonfermenting, yeast, homolog)-like 2 | |
| SNF2/SWI2-like protein 2 | |
| SNF2A | |
| SNF2-alpha | |
| SNF2-like 2 | |
| Sth1p | |
| SNF2/SWI2-like protein II | |
| SNF2-like II | |
| 2310032M22Rik | |
| 2610209L14Rik | |
| sucrose nonfermenting 2-like protein 2 | |
| hSNF2a | |
| SNF2L2 | |
| SNF2 (sucrose nonfermenting, yeast, homolog)-like II | |
| SNF2LA | |
| RIKEN cDNA 2310032M22 gene |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 8223438 |
|---|---|
| 8670841 | |
| 9843504 | |
| 11163203 | |
| 11318604 | |
| 12437990 | |
| 12466851 | |
| 9603422 |
| LocusLink ID | 6595 |
|---|---|
| 67155 | |
| 497742 | |
| 20584 | |
| 95083 | |
| 361745 |
| FunctionalClass | ATP binding |
|---|---|
| DNA binding | |
| helicase | |
| hydrolase | |
| nucleotide binding | |
| transcription coactivator | |
| nucleic acid binding | |
| protein binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| SWI/SNF complex | |
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | GR |
|---|
| GO Biological Process | regulation of transcription from RNA polymerase II promoter |
|---|---|
| transcription | |
| establishment and/or maintenance of chromatin architecture | |
| negative regulation of cell proliferation | |
| nucleosome assembly | |
| regulation of transcription, DNA-dependent | |
| regulation of cell proliferation |
| Group | Transcription factors |
|---|
| Source | Curated |
|---|