| Name | CEBPA |
|---|---|
| Description | CCAAT/enhancer binding protein (C/EBP), alpha |
| Owner | Public |
| URN | urn:agi-llid:1050 |
| Connectivity | 256 |
| Notes | The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells. |
| Hugo ID | 1833 |
| Microarray ID | 1369658_at |
|---|---|
| rc_ai236300_at | |
| x12752_at | |
| A_43_P15494 | |
| msa.506.0_at | |
| A_65_P07871 | |
| A_51_P214087 | |
| A_52_P168567 | |
| A_14_P129150 | |
| A_14_P115495 | |
| A_14_P139438 | |
| A_24_P224727 | |
| A_24_P216165 | |
| A_23_P208798 | |
| 32550_r_at | |
| 61119_at | |
| 204039_at | |
| U34070_s_at | |
| rc_n39553_at | |
| A_23_P375494 | |
| E226 | |
| OH8471 | |
| OR3912 | |
| RT108 |
| Chromosome position | 19q13.1 |
|---|---|
| 7 12.0 cM |
| GO ID | 0016563 |
|---|---|
| 0016564 | |
| 0001892 | |
| 0003677 | |
| 0005515 | |
| 0005667 | |
| 0007005 | |
| 0008285 | |
| 0030225 | |
| 0042803 | |
| 0045444 | |
| 0003705 | |
| 0005634 | |
| 0006091 | |
| 0006350 | |
| 0006355 | |
| 0006366 | |
| 0008134 | |
| 0019221 | |
| 0030099 |
| Alias | 1500003K14Rik |
|---|---|
| B430104H02Rik | |
| CGI-105 | |
| CCAAT/enhancer binding (C/EBP) | |
| C/EBP alpha | |
| CAAT/enhancer-binding protein, DNA-binding protein | |
| CCAAT/enhancer binding protein (C/EBP), alpha | |
| CCAAT/enhancer binding protein alpha | |
| CEBP | |
| DBPCEP | |
| CCAAT/enhancer binding | |
| RIKEN cDNA B430104H02 gene | |
| C/EBP | |
| Cebpa | |
| CGI-105s | |
| LOC51011 |
| Organism | Rattus norvegicus |
|---|---|
| Mus musculus | |
| Homo sapiens |
| MedLine Reference | 12020822 |
|---|---|
| 2850264 | |
| 10075730 | |
| 10082561 | |
| 10510303 | |
| 11940593 | |
| 12037571 | |
| 12502791 | |
| 12821655 | |
| 12861022 | |
| 15073037 | |
| 15509779 | |
| 15519652 | |
| 15664994 | |
| 7575576 | |
| 8643605 |
| LocusLink ID | 24252 |
|---|---|
| 12606 | |
| 1050 |
| FunctionalClass | transcriptional activator |
|---|---|
| transcriptional repressor | |
| DNA binding | |
| protein binding | |
| protein homodimerization | |
| RNA polymerase II transcription factor activity, enhancer binding | |
| transcription factor binding |
| RGD ID | 2326 |
|---|
| Hugo Symbol | CEBPA |
|---|
| Unigene ID | Hs.76171 |
|---|---|
| Mm.349667 | |
| Rn.22163 |
| GO Cellular Component | transcription factor complex |
|---|---|
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | TLR4 -> CEBPA signalling pathway |
|---|---|
| IGF1R -> CEBPA signalling pathway | |
| IL6R -> CEBPA signalling pathway | |
| IL6ST -> CEBPA signalling pathway | |
| CD4 -> CEBPA signalling pathway | |
| TNFRSF5 -> CEBPA signalling pathway | |
| EPOR -> CEBPA signalling pathway | |
| FGFR1 -> CEBPA signalling pathway | |
| FLT3 -> CEBPA signalling pathway | |
| MPL -> CEBPA signalling pathway | |
| CSF3-CSF3R | |
| CSF3-IL6R | |
| EGF-ERBB2 | |
| EGF-ERBB3 | |
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| FGF2-CD44 | |
| FGF2-FGFR1 | |
| FGF2-FGFR2 | |
| FGF2-FGFR3 | |
| FGF2-GPC1 | |
| FGF2-TGFBR3 | |
| FGF7-FGFR2 | |
| FGF7-GPC1 | |
| GDF8-ACVR2 | |
| GH1-GHR | |
| GH1-IGF1R | |
| GH1-PRLR | |
| HGF-CD44 | |
| HGF-FGFR2 | |
| HGF-IL6R | |
| HGF-MET | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| IL13-IL13RA1 | |
| IL13-IL13RA2 | |
| IL13-IL2RG | |
| IL4-FCER2 | |
| IL4-IL2RG | |
| IL4-IL4R | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-TFRC | |
| LEP-LEPR | |
| LEP-LRP2 | |
| LIF-IGF2R | |
| LIF-IL6ST | |
| LIF-LIFR | |
| OSM-CD22 | |
| OSM-IL6ST | |
| OSM-LIFR | |
| PRL-PRLR | |
| PTH-IL6ST | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1B | |
| TNFSF5-CD28 | |
| TNFSF5-CD80 | |
| TNFSF5-TNFRSF5 | |
| TNFSF5-TNFRSF6 | |
| TNFSF5-TNFRSF7 | |
| TNFSF5-TNFRSF8 | |
| WNT1-LRP5 | |
| WNT1-LRP6 | |
| WNT1-ROR2 | |
| DuPont 4 | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| GR | |
| HNF4a | |
| TR |
| GO Biological Process | adipocyte differentiation |
|---|---|
| embryonic placenta development | |
| fat cell differentiation | |
| macrophage differentiation | |
| mitochondrion organization and biogenesis | |
| negative regulation of cell proliferation | |
| cytokine and chemokine mediated signaling pathway | |
| generation of precursor metabolites and energy | |
| myeloid cell differentiation | |
| regulation of transcription, DNA-dependent | |
| transcription | |
| transcription from RNA polymerase II promoter |
| Group | Transcription factors |
|---|
| MGI ID | 99480 |
|---|
| Swiss-Prot Accession | P49715 |
|---|
| OMIM ID | 116897 |
|---|---|
| 601626 |
| Source | Curated |
|---|