Protein : STAT5B


Name	STAT5B
Description	signal transducer and activator of transcription 5B
Owner	Public
URN	urn:agi-llid:6777
Connectivity	66
Notes	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Hugo ID	11367


Alias	D130012G24Rik
	RIKEN cDNA D130012G24 gene
	signal transducer and activator of transcription 5
	signal transducer and activator of transcription 5B
	Stat5b
	signal transducer and activator of transcription V
	transcription factor STAT5B


RGD ID	3774


Hugo Symbol	STAT5B


KEGG pathway	Jak-STAT signaling pathway


GO Cellular Component	nucleus
	cytoplasm


Cell Localization	Nucleus


Pathway	TPO
	Prolactin
	Leptin
	IL9
	IL7
	IL5
	IL3
	IL2
	IL15
	Growth Hormone
	GM-CSF
	EPO
	IL3RA -> STAT5B signalling pathway
	IL6ST -> STAT5B signalling pathway
	LEPR -> STAT5B signalling pathway
	CD4 -> STAT5B signalling pathway
	ERBB2 -> STAT5B signalling pathway
	ERBB4 -> STAT5B signalling pathway
	FGFR3 -> STAT5B signalling pathway
	GHR -> STAT5B signalling pathway
	PRLR -> STAT5B signalling pathway
	EGFR -> STAT5B signalling pathway
	BTC-EGFR
	CSF1-CSF1R
	CSF1-IL6R
	CSF1-TNFRSF5
	CSF2-CSF2RA
	CSF3-CSF3R
	CSF3-IL6R
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	EPO-EPOR
	GH1-GHR
	GH1-IGF1R
	GH1-PRLR
	IFNA1-CR2
	IFNA1-IFNAR1
	IFNA1-IFNAR2
	IFNG-HLA-C
	IFNG-IFNGR1
	IFNG-IFNGR2
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	IL2-IL15RA
	IL2-IL2RA
	IL2-IL2RB
	IL2-IL4R
	IL3-CD8A
	IL3-CSF2RB2
	IL3-EPOR
	IL3-IL3RA
	IL4-FCER2
	IL4-IL2RG
	IL4-IL4R
	IL5-IL5RA
	IL5-IL6ST
	IL6-IL6R
	IL6-IL6ST
	IL6-LIFR
	IL6-TNFRSF5
	IL7-IL2RG
	IL7-IL7R
	INS-EGFR
	INS-HLA-DRB1
	INS-TFRC
	LEP-LEPR
	LEP-LRP2
	NRG1-CD44
	NRG1-EGFR
	NRG1-ERBB2
	NRG1-ERBB3
	NRG1-ERBB4
	PRL-PRLR
	TGFA-EGFR
	THPO-EPOR
	THPO-MPL
	PPAR all
	PPARalpha
	ERalpha
	GR


GO Biological Process	regulation of transcription from Pol II promoter
	JAK-STAT cascade
	intracellular signaling cascade
	regulation of transcription from RNA polymerase II promoter
	transcription
	T cell homeostasis
	cytokine and chemokine mediated signaling pathway
	development of secondary female sexual characteristics
	development of secondary male sexual characteristics
	lactation
	lipid storage
	luteinization
	natural killer cell differentiation
	negative regulation of apoptosis
	negative regulation of erythrocyte differentiation
	positive regulation of B cell differentiation
	positive regulation of activated T cell proliferation
	positive regulation of body size
	positive regulation of cell proliferation
	positive regulation of inflammatory response
	positive regulation of interleukin-2 biosynthesis
	positive regulation of mitotic cell cycle
	positive regulation of survival gene product
	positive regulation of transcription from RNA polymerase II promoter
	pregnancy
	progesterone metabolism
	regulation of cell adhesion
	regulation of epithelial cell differentiation
	regulation of steroid metabolism
	regulation of transcription, DNA-dependent
	signal transduction


Group	Sh2
	Transcription factors


MGI ID	103035
	2444865


Swiss-Prot Accession	P51692


OMIM ID	604260
	245590


Source	Curated