| Name | STAT6 |
|---|---|
| Description | signal transducer and activator of transcription 6, interleukin-4 induced |
| Owner | Public |
| URN | urn:agi-llid:6778 |
| Connectivity | 79 |
| Notes | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. |
| Hugo ID | 11368 |
| Microarray ID | 1421708_a_at |
|---|---|
| l47650_s_at | |
| msa.12937.0_s_at | |
| u66575_rc_at | |
| A_65_P00601 | |
| A_51_P452382 | |
| U16031 | |
| 201331_s_at | |
| 201332_s_at | |
| 212803_at | |
| 41222_at | |
| 845_at | |
| U16031_at | |
| rc_aa291950_at | |
| A_23_P47879 | |
| A_14_P137148 | |
| A_14_P133936 | |
| A_14_P127436 | |
| M92 | |
| 562 | |
| OH3129A |
| Chromosome position | 10 70.0 cM |
|---|---|
| 12q13 |
| GO ID | 0003677 |
|---|---|
| 0005737 | |
| 0006355 | |
| 0007165 | |
| 0042127 | |
| 0003700 | |
| 0004871 | |
| 0005509 | |
| 0005634 | |
| 0006350 | |
| 0006357 | |
| 0007242 |
| Alias | RIKEN cDNA 9330109E03 gene |
|---|---|
| 9330109E03Rik | |
| D12S1644 | |
| IL-4 Stat | |
| signal transducer and activator of transcription 6 | |
| signal transducer and activator of transcription 6, interleukin-4 induced | |
| Signal transducer and activator of transcription-6, interleukin-4 | |
| STAT, interleukin4-induced | |
| STAT6B | |
| STAT6C | |
| signal transducer and activator of transcription VI | |
| transcription factor IL-4 STAT | |
| Signal transducer and activator of transcription-6, interleukin IV | |
| Stat6 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MedLine Reference | 12093868 |
|---|---|
| 12634107 | |
| 10747856 | |
| 8810328 |
| LocusLink ID | 6778 |
|---|---|
| 216450 | |
| 20852 | |
| 320852 |
| FunctionalClass | DNA binding |
|---|---|
| calcium ion binding | |
| signal transducer | |
| transcription factor |
| Hugo Symbol | STAT6 |
|---|
| Unigene ID | Mm.121721 |
|---|---|
| Hs.524518 | |
| Mm.257783 |
| GO Cellular Component | nucleus |
|---|---|
| cytoplasm |
| Cell Localization | Nucleus |
|---|
| Pathway | Leptin |
|---|---|
| IL4 | |
| IL13 | |
| IL2RG -> STAT6 signalling pathway | |
| IL4R -> STAT6 signalling pathway | |
| KDR -> STAT6 signalling pathway | |
| CD4 -> STAT6 signalling pathway | |
| CD28 -> STAT6 signalling pathway | |
| TNFRSF5 -> STAT6 signalling pathway | |
| PTPRC -> STAT6 signalling pathway | |
| AGT-LRP2 | |
| CD86-CR2 | |
| CSF1-TNFRSF5 | |
| CSF2-CSF2RA | |
| IFNA1-CR2 | |
| IFNA1-IFNAR1 | |
| IFNA1-IFNAR2 | |
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| IGF1-BST1 | |
| IGF1-IGF2R | |
| IGF1-LRP5 | |
| IL10-IL10RA | |
| IL10-TNFRSF7 | |
| IL13-IL13RA1 | |
| IL13-IL13RA2 | |
| IL13-IL2RG | |
| IL13-IL4R | |
| IL15-IL15RA | |
| IL15-IL2RB | |
| IL15-IL2RG | |
| IL2-IL15RA | |
| IL2-IL2RA | |
| IL2-IL2RB | |
| IL2-IL4R | |
| IL3-CD8A | |
| IL3-CSF2RB2 | |
| IL3-EPOR | |
| IL3-IL3RA | |
| IL4-FCER2 | |
| IL4-IL2RG | |
| IL4-IL4R | |
| IL5-IL5RA | |
| IL5-IL6ST | |
| IL6-IL6R | |
| IL6-IL6ST | |
| IL6-LIFR | |
| IL7-IL2RG | |
| IL7-IL7R | |
| IL9-IL9R | |
| OSM-CD22 | |
| OSM-IL6ST | |
| OSM-LIFR | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-CD44 | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| TNF-IL15RA | |
| TNF-NGFR | |
| TNF-TNFRSF1B | |
| TNFSF5-TNFRSF6 | |
| TNFSF5-TNFRSF7 | |
| TNFSF5-TNFRSF8 | |
| TNFSF7-TNFRSF5 | |
| TNFSF9-TNFRSF5 | |
| VEGF-CD44 | |
| GR |
| GO Biological Process | intracellular signaling cascade |
|---|---|
| regulation of transcription from RNA polymerase II promoter | |
| transcription | |
| regulation of cell proliferation | |
| regulation of transcription, DNA-dependent | |
| signal transduction | |
| regulation of transcription from Pol II promoter |
| Group | Sh2 |
|---|---|
| Transcription factors |
| MGI ID | 103034 |
|---|---|
| 2444866 |
| Swiss-Prot Accession | P42226 |
|---|
| OMIM ID | 601512 |
|---|
| Source | Curated |
|---|