| Name | Ppp5c |
|---|---|
| Description | protein phosphatase 5, catalytic subunit |
| Owner | Public |
| URN | urn:agi-llid:5536 |
| Connectivity | 25 |
| Notes | PP5 is regulated by mTOR and activates apoptosis signal-regulating kinase 1 signaling. PP5 plays an important role in the survival of cells in a low oxygen environment by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes an apoptotic response. PP5 suppresses a pathway regulating the expression of p21(waf1). Results describe the structure of the autoinhibited state of protein phosphatase 5, revealing mechanisms of tetratricopeptide repeat-mediated phosphatase inhibition and Hsp90- and arachidonic acid-induced stimulation of phosphatase activity. Protein phosphatase 5 interacts with DNA-PKcs and dephosphorylates with surprising specificity at least two functional sites. Structure of Serine/threonine protein phosphatase-5(PP5c) provides a structural basis for explaining the exceptional catalytic proficiency of protein phosphatases. |
| Microarray ID | 1398242_at |
|---|---|
| x77237_at | |
| A_42_P740149 | |
| A_51_P307242 | |
| A_51_P307243 | |
| A_52_P323669 | |
| U25174 | |
| 215705_at | |
| 201979_s_at | |
| 391_at | |
| 392_g_at | |
| X89416_at | |
| rc_aa022512_s_at | |
| rc_t64887_f_at | |
| A_23_P153581 | |
| A_14_P118916 | |
| A_23_P153583 | |
| A_14_P136374 | |
| N331 | |
| OH2816 | |
| OR3138 | |
| MA857 | |
| RA0152 |
| Chromosome position | 1q21 |
|---|---|
| 7 4.0 cM | |
| 19q13.3 |
| GO ID | 0004722 |
|---|---|
| 0004871 | |
| 0005488 | |
| 0005506 | |
| 0005634 | |
| 0005737 | |
| 0006350 | |
| 0006470 | |
| 0007067 | |
| 0016787 | |
| 0030145 | |
| 0043123 | |
| 0046872 | |
| 0000158 | |
| 0000163 | |
| 0004723 | |
| 0004724 | |
| 0008287 | |
| 0008420 | |
| 0015071 | |
| 0017018 | |
| 0019904 | |
| 0030357 | |
| 0004721 | |
| 0005515 | |
| 0005829 |
| Alias | ANP receptors |
|---|---|
| ANP receptor | |
| catalytic subunit protein phosphatase 5 | |
| protein phosphatase 5, catalytic subunit | |
| catalytic subunit protein phosphatase V | |
| Ppp5c | |
| PP-5 | |
| PP(5) | |
| PP-T |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 12885400 |
|---|---|
| 12761501 | |
| 7925273 | |
| 7972012 |
| LocusLink ID | 19060 |
|---|---|
| 101758 | |
| 5536 | |
| 65179 |
| FunctionalClass | CTD phosphatase |
|---|---|
| calcium-dependent protein serine/threonine phosphatase | |
| hydrolase | |
| iron ion binding | |
| manganese ion binding | |
| metal ion binding | |
| protein serine/threonine phosphatase | |
| signal transducer | |
| magnesium-dependent protein serine/threonine phosphatase | |
| myosin phosphatase | |
| protein domain specific binding | |
| protein phosphatase type 1 | |
| protein phosphatase type 2A | |
| protein phosphatase type 2B | |
| protein phosphatase type 2C | |
| binding | |
| phosphoprotein phosphatase | |
| protein binding |
| KEGG pathway | MAPK signaling pathway |
|---|
| GO Cellular Component | cytoplasm |
|---|---|
| nucleus | |
| protein serine/threonine phosphatase complex | |
| cytosol |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | ERbeta |
|---|---|
| ERalpha | |
| GR |
| GO Biological Process | mitosis |
|---|---|
| positive regulation of I-kappaB kinase/NF-kappaB cascade | |
| protein amino acid dephosphorylation | |
| transcription |
| Group | Phosphatases |
|---|
| EC Number | 3.1.3.16 |
|---|
| Source | Curated |
|---|