| Name | FKBP5 |
|---|---|
| Description | FK506 binding protein 5 |
| Owner | Public |
| URN | urn:agi-llid:2289 |
| Connectivity | 9 |
| Notes | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. |
| Hugo ID | 3721 |
| Microarray ID | 1448231_at |
|---|---|
| u36220_s_at | |
| A_51_P383689 | |
| A_52_P337899 | |
| 224856_at | |
| 224840_at | |
| 34721_at | |
| 46271_at | |
| 204560_at | |
| RC_AA435612_at | |
| U42031_at | |
| A_23_P111206 | |
| A_14_P117671 | |
| A_14_P119832 | |
| A_24_P38081 | |
| OH0995 | |
| S97 |
| Chromosome position | 17 13.0 cM |
|---|---|
| 6p21.3-21.2 |
| GO ID | 0005488 |
|---|---|
| 0003755 | |
| 0005528 | |
| 0005634 | |
| 0006457 | |
| 0016853 | |
| 0051082 |
| Alias | DNA segment, Chr 17, ERATO Doi 592, expressed |
|---|---|
| similar to FK506 binding protein 5 (51 kDa) | |
| 51 kDa FK506-binding protein | |
| 54 kDa progesterone receptor-associated immunophilin | |
| D17Ertd592e | |
| Dit1 | |
| FF1 antigen | |
| FK506 binding protein 5 | |
| FK506 binding protein 5 (51 kDa) | |
| FKBP51 | |
| Ptg-10 | |
| FK506 binding protein V | |
| 51 kDa FK506-binding protein V | |
| FKBP54 | |
| 51 kDa FK506-binding protein 5 | |
| FKBP5 | |
| T-cell FK506-binding protein | |
| Ptg X | |
| Dit I | |
| HSP90-binding immunophilin | |
| FKBP54s | |
| FKBP51s |
| Organism | Mus musculus |
|---|---|
| Homo sapiens |
| MedLine Reference | 9001212 |
|---|
| LocusLink ID | 52022 |
|---|---|
| 2289 | |
| 14229 |
| FunctionalClass | FK506 binding |
|---|---|
| isomerase | |
| peptidyl-prolyl cis-trans isomerase | |
| unfolded protein binding |
| Hugo Symbol | FKBP5 |
|---|
| Unigene ID | Hs.407190 |
|---|---|
| Mm.276405 |
| GO Cellular Component | nucleus |
|---|
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | INS-HLA-DRB1 |
|---|---|
| INS-TFRC | |
| ERalpha | |
| GR |
| GO Biological Process | protein folding |
|---|
| Group | Metabolic enzymes |
|---|
| EC Number | 5.2.1.8 |
|---|
| MGI ID | 104670 |
|---|
| Swiss-Prot Accession | Q13451 |
|---|
| OMIM ID | 602623 |
|---|
| Source | Curated |
|---|