Protein : HIF1A


Name	HIF1A
Description	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Owner	Public
URN	urn:agi-llid:3091
Connectivity	123
Notes	Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.
Hugo ID	4910


Alias	pasd8
	ARNT interacting protein
	hypoxia-inducible factor 1 DNA-binding subunit
	ARNT interactive protein
	Member of PAS protein I
	member of PAS superfamily 1
	member of PAS superfamily I
	Hif1a
	HIF-1alpha
	Hypoxia-inducible factor 1 alpha
	hypoxia-inducible factor 1, alpha subunit
	Member of PAS protein 1
	MOP I
	MOP1


FunctionalClass	RNA polymerase II transcription factor
	double-stranded DNA binding
	DNA binding
	protein binding
	transcription factor
	transcription regulator
	RNA polymerase II transcription factor activity, enhancer binding
	histone acetyltransferase binding
	protein heterodimerization
	signal transducer


RGD ID	61928


Hugo Symbol	HIF1A


GO Cellular Component	nucleus
	flagellum (sensu Eukaryota)


Cell Localization	Nucleus


Pathway	TNFRSF6 -> HIF1A signalling pathway
	IGF1R -> HIF1A signalling pathway
	KDR -> HIF1A signalling pathway
	ERBB2 -> HIF1A signalling pathway
	FLT1 -> HIF1A signalling pathway
	EDNRA -> HIF1A signalling pathway
	EGFR -> HIF1A signalling pathway
	AGT-LRP2
	CCL2-CD4
	EGF-ERBB2
	EGF-ERBB3
	EGF-ERBB4
	EGF-LRP8
	EGF-NGFR
	F2-ITGAV
	F2-LRP1
	F2-LRP2
	F2-THBD
	FGF2-CD44
	FGF2-FGFR1
	FGF2-FGFR2
	FGF2-FGFR3
	FGF2-GPC1
	FGF2-TGFBR3
	HGF-CD44
	HGF-FGFR2
	HGF-IL6R
	HGF-MET
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	IGF2-IGF1R
	IGF2-IGF2R
	IL15-IL15RA
	IL15-IL2RB
	IL15-IL2RG
	IL1B-HLA-DRB1
	IL1B-IL1R1
	IL1B-IL1RAP
	IL1B-IL6R
	INS-EGFR
	INS-HLA-DRB1
	INS-TFRC
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	TAC1-TNFRSF11B
	TGFB1-ACVR1
	TGFB1-ACVR1B
	TGFB1-ACVR2
	TGFB1-ACVR2B
	TGFB1-ACVRL1
	TGFB1-BMPR1B
	TGFB1-CD44
	TGFB1-IGF2R
	TGFB1-IL6R
	TGFB1-M6PR
	TGFB1-SELE
	TGFB1-SELL
	TGFB1-TGFBR1
	TGFB1-TGFBR2
	TGFB1-TGFBR3
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1B
	ERalpha
	GR
	NR common targets


GO Biological Process	electron transport
	homeostasis
	regulation of transcription, DNA-dependent
	response to hypoxia
	signal transduction
	angiogenesis
	cell differentiation
	positive regulation of transcription from RNA polymerase II promoter
	regulation of apoptosis
	regulation of transcription
	transcription


Group	Transcription factors


State	hypoxia-inducible factor 1, alpha subunit isoform 1
	hypoxia-inducible factor 1, alpha subunit isoform 2


State Description	Transcript Variant: This variant (1) encodes the predominant isoform (1).
	Transcript Variant: This variant (2) lacks an alternate segment in the 3' CDS, compared to variant 1, that results in a frameshift. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.


MGI ID	106918


Swiss-Prot Accession	Q16665


OMIM ID	603348


Source	Curated