Protein : FOS

Name FOS
Description v-fos FBJ murine osteosarcoma viral oncogene homolog
Owner Public
URN urn:agi-llid:2353
Connectivity 325
Notes The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.
Hugo ID 3796

Microarray ID 1371283_at
x03347cds_g_at
x06769cds_at
x06769cds_g_at
A_42_P552092
100490_at
A_65_P03817
A_51_P333146
A_52_P262219
V01512
229173_at
71524_at
88628_at
209189_at
1915_s_at
1916_s_at
2094_s_at
V01512_rna1_at
rc_n23730_s_at
A_32_P75334
A_23_P106192
A_14_P107571
A_14_P117160
A_23_P106194
M494
C277
OH8074
OR3846
MB484
R549
OR0720
203358_Rn
160901_at
1423100_at
97628_at
161716_at
v00727_s_at
Msa.2013.0_at
A_65_P07422
H3084G03-3
NM_010234.1
NM_010234
234463_at
I_959033

GenBank ID AAA96699
AAH29814
AAR00345
AK154418
AK159688
AY423854
BAE32571
BC013242
BC029814
CAA24105
J00370
M23768
NC_000078
NM_010234
NP_034364
NT_039551
P01101
V00727
CR541785
CR542267
K00650
NC_000014
NM_005252
NP_005243
NT_026437
NT_086807
P01100
V01512
AAA52471
AAC98315
AAH04490
AAO21129
AB022275
AB022276
AF111167
AK097379
AY212879
BAA87920
BAA87921
BC004490
BX647104
CAA24756
CAG46584
CAG47063
AAA42348
AAG47951
AAV33852
AAV33853
AAV33854
AAV41063
AAW65541
AAW65542
AAZ13764
AF126534
AF277645
AI059251
AY780201
AY780202
AY780203
AY786174
AY828998
AY828999
BF547581
CAA29937
DQ089699
M34001
NC_005105
NM_022197
NP_071533
NW_047762
P12841
U02631
X06769
XM_234422
6518634
27802688
34935858
34867433
34867434
4836596
12056583
12056584
413826
55933
55934
51766990
31560587
6753894
193342
387161
192565
50399
50400
15301524
20988256
20988257
120471
27802689
4063509
6518635
4572570
182734
182735
29903
29904
21757114
33872858
13325364
34366132
49456526
49456527
49457527
49457528
120470
68869
68871
NW_043958
207684
207685
3333028
11638646
XP_234422
51493278
6552332
4885241
51472322
6518628
6518629

Chromosome position 12 40.0 cM
6q31
14q24.3

GO ID GO:0005622
GO:0007048
GO:0006366
GO:0003677
GO:0003700
GO:0008151
GO:0006355
GO:0007399
GO:0000074
GO:0005634
GO:0005667
0000074
0003700
0005667
0006355
0007399
0050875
0003677
0003704
0005634
0006306
0006357
0006954
0003690
0046982
0045941
GO:0003704
GO:0006306
GO:0006357
GO:0006954

Alias Fos
similar to Proto-oncogene protein c-fos (Cellular oncogene fos)
FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)
Manh14
mandible shape 14
Manh14s
QTL-SH10.2
Cellular oncogene C-FOS
D12Rfj1
FBJ murine osteosarcoma viral (v-fos) oncogene homolog
FBJ osteosarcoma oncogene
Proto-oncogene protein c-fos (Cellular oncogene fos)
FOS_HUMAN
c-fos
transforming protein fos
D12Rfj I
P55-C-FOS proto-oncogene protein
v-fos FBJ murine osteosarcoma viral oncogene homolog
FBJ murine osteosarcoma viral
v-fos) oncogene homolog (oncogene FOS
wb-fos protein gene
c-fos oncogene
proto-oncogene cfos
proto-oncogene c-fos
G0S7 proteins
v-fos
cellular oncogene fos
G0S7 protein

Organism Mus musculus
Rattus norvegicus
Homo sapiens
Human
rat
mouse

MedLine Reference 11925568
12220541
12486129
12943993
10918580
9443941
9888853
11747369

LocusLink ID 114281
14281
314322
24371
60585
2353

FunctionalClass transcription factor
DNA binding
specific RNA polymerase II transcription factor

RGD ID 2626
735054

Hugo Symbol FOS

Unigene ID Rn.103750
Mm.246513
Hs.25647
Mm.5043

Keyword transcription factor
nucleus
early growth response
RAS small monomeric GTPase
oncogene
leucine zipper
bzip transcription factor
hnRNA
antisense RNA
cytoplasm
factor C
DNA bending
RNA
thrombin
DNA binding activity
binding activity
cytosol
nuclei
septum
leucine repeat
basic leucine zipper
growth-associated

GO Cellular Component transcription factor complex
nucleus
intracellular

GO Molecular Function DNA binding
transcription factor activity
specific RNA polymerase II transcription factor activity
DNA binding activity
specific RNA polymerase II transcription factor

Cell Localization Nucleus
Cytoplasm

Pathway p40 MAPK
PDGF signaling
Insulin pathway
IL-6 signaling
IL-3 signaling
IL-2 signaling
Erythropoietin signaling
EGF signaling
MAPK-ERK in Growth and Differentiation
NGF signaling
KITLG
IL1
EPHB1
NCAM1 -> FOS signalling pathway
NGFR -> FOS signalling pathway
NOTCH1 -> FOS signalling pathway
NTRK1 -> FOS signalling pathway
NTRK3 -> FOS signalling pathway
OPRD1 -> FOS signalling pathway
OPRM1 -> FOS signalling pathway
TNFRSF1A -> FOS signalling pathway
ADORA1 -> FOS signalling pathway
AGTR1 -> FOS signalling pathway
AGTR2 -> FOS signalling pathway
HTR2A -> FOS signalling pathway
ICAM1 -> FOS signalling pathway
ICAM2 -> FOS signalling pathway
TNFRSF6 -> FOS signalling pathway
IGF1R -> FOS signalling pathway
IL1R1 -> FOS signalling pathway
IL2RB -> FOS signalling pathway
IL6ST -> FOS signalling pathway
KLRG1 -> FOS signalling pathway
KIT -> FOS signalling pathway
SEMA6B -> FOS signalling pathway
CCKAR -> FOS signalling pathway
CCKBR -> FOS signalling pathway
LEPR -> FOS signalling pathway
CD4 -> FOS signalling pathway
CD19 -> FOS signalling pathway
CD28 -> FOS signalling pathway
TNFRSF5 -> FOS signalling pathway
EPOR -> FOS signalling pathway
FCGR3A -> FOS signalling pathway
FGFR2 -> FOS signalling pathway
FLT1 -> FOS signalling pathway
SELE -> FOS signalling pathway
FSHR -> FOS signalling pathway
GHR -> FOS signalling pathway
SSTR1 -> FOS signalling pathway
GNRHR -> FOS signalling pathway
TACR1 -> FOS signalling pathway
GRIA2 -> FOS signalling pathway
GRIA3 -> FOS signalling pathway
GRIN1 -> FOS signalling pathway
GRM2 -> FOS signalling pathway
GRM5 -> FOS signalling pathway
PDGFRB -> FOS signalling pathway
EDG5 -> FOS signalling pathway
PLAUR -> FOS signalling pathway
CSF1R -> FOS signalling pathway
PTGFR -> FOS signalling pathway
PTPRJ -> FOS signalling pathway
DRD1 -> FOS signalling pathway
DRD2 -> FOS signalling pathway
DRD3 -> FOS signalling pathway
EDNRA -> FOS signalling pathway
EDNRB -> FOS signalling pathway
EGFR -> FOS signalling pathway
MET -> FOS signalling pathway
AGT-LRP2
B7H2-CD28
BDNF-NCAM1
BDNF-NGFR
BDNF-NTRK1
BDNF-NTRK2
BDNF-NTRK3
BMP2-ACVR1
BMP2-ACVR2
BMP2-BMPR1A
BMP2-BMPR1B
BMP2-BMPR2
CNTF-CNTFR
CNTF-IL6ST
CNTF-LIFR
CSF1-CSF1R
CSF1-IL6R
CSF1-TNFRSF5
CSF2-CSF2RA
CSF3-CSF3R
CSF3-IL6R
CTF1-IL6ST
EGF-EGFR
EGF-ERBB2
EGF-ERBB3
EGF-ERBB4
EGF-LRP8
EGF-NGFR
F2-ITGAV
F2-LRP1
F2-LRP2
F2-THBD
FGF1-FGFR1
FGF1-FGFR2
FGF1-FGFR3
FGF1-GPC1
FGF2-CD44
FGF2-FGFR1
FGF2-FGFR2
FGF2-FGFR3
FGF2-GPC1
FGF2-TGFBR3
FIGF-FLT4
FIGF-KDR
GDNF-RET
GH1-GHR
GH1-IGF1R
GH1-PRLR
HGF-CD44
HGF-FGFR2
HGF-IL6R
HGF-MET
IFNA1-CR2
IFNA1-IFNAR1
IFNA1-IFNAR2
IFNB1-IFNAR1
IFNG-HLA-C
IFNG-IFNGR1
IFNG-IFNGR2
IGF1-BST1
IGF1-IGF1R
IGF1-IGF2R
IGF1-LRP5
IL10-IL10RA
IL10-TNFRSF7
IL16-CD4
IL1A-IL1R1
IL1A-IL1RAP
IL1B-HLA-DRB1
IL1B-IL1R1
IL1B-IL1RAP
IL1B-IL6R
IL2-IL15RA
IL2-IL2RA
IL2-IL2RB
IL2-IL2RG
IL2-IL4R
IL3-CD8A
IL3-CSF2RB2
IL3-EPOR
IL3-IL3RA
IL4-FCER2
IL4-IL2RG
IL4-IL4R
IL5-IL5RA
IL5-IL6ST
IL6-IL6R
IL6-IL6ST
IL6-LIFR
IL6-TNFRSF5
IL7-IL2RG
IL7-IL7R
INS-EGFR
INS-HLA-DRB1
INS-IGF1R
INS-TFRC
KITLG-KIT
LEP-LEPR
LEP-LRP2
LIF-IGF2R
LIF-IL6ST
LIF-LIFR
NGFB-NGFR
NGFB-NTRK1
NGFB-NTRK2
NGFB-NTRK3
NMU-TGFBR1
NPPA-NPTXR
NTF3-CNTFR
NTF3-NGFR
NTF3-NTRK1
NTF3-NTRK2
NTF3-NTRK3
NTF5-NGFR
NTF5-NTRK1
NTF5-NTRK2
NTF5-NTRK3
OSM-CD22
OSM-IL6ST
OSM-LIFR
PDGFA-PDGFRB
PGF-FLT1
PGF-KDR
PRL-PRLR
PTH-IL6ST
SDF1-CD4
SDF1-IL6ST
TAC1-TNFRSF11B
TGFA-EGFR
TGFB1-ACVR1
TGFB1-ACVR1B
TGFB1-ACVR2
TGFB1-ACVR2B
TGFB1-ACVRL1
TGFB1-BMPR1B
TGFB1-CD44
TGFB1-IGF2R
TGFB1-IL6R
TGFB1-M6PR
TGFB1-SELE
TGFB1-SELL
TGFB1-TGFBR1
TGFB1-TGFBR2
TGFB1-TGFBR3
THPO-EPOR
THPO-MPL
TNF-IL15RA
TNF-NGFR
TNF-TNFRSF1A
TNF-TNFRSF1B
TNF-TNFRSF6
TNFSF10-TNFRSF10A
TNFSF10-TNFRSF10B
TNFSF10-TNFRSF1A
TNFSF10-TNFRSF6
TNFSF11-TNFRSF11A
TNFSF11-TNFRSF11B
TNFSF6-TNFRSF6
TNFSF7-CD28
VEGF-CD44
VEGF-EGFR
VEGF-FLT1
VEGF-FLT4
VEGF-GPC1
VEGF-IL1R1
VEGF-KDR
CLADiff
Ben Common regulators
ERalpha
GR
NR common targets
Donna's proteomics

Compartment void
nucleus

GO Biological Process cellular physiological process
neurogenesis
regulation of progression through cell cycle
regulation of transcription, DNA-dependent
DNA methylation
inflammatory response
regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
positive regulation of transcription
regulation of transcription from Pol II promoter
cell growth and/or maintenance
oncogenesis
cell growth and maintenance
transcription from Pol II promoter
transcription regulation from Pol II promoter

Group Transcription factors
CLA Diff

RefSeq ACCNUM NP_005243

Proteome Subcellular Localization Nuclear

Proteome Biochemical Function DNA-binding protein

State p

Proteome Cellular Role Chromatin/chromosome structure
Pol II transcription

MGI ID 95574
2148821

Swiss-Prot Accession P01100

OMIM ID 164810
OMIM:164810
2148821

Source Curated
BIND
ResNet