| Entities | NR3C1 ---- casein |
|---|---|
| References | 10 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-protfc:casein:inout-urn:agi-llid:2908::positive |
| Tissue | mammary |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v21 i9 p3266 (2001) |
| Journal Link | http://mcb.asm.org/cgi/content/full/21/9/3266 |
| MedLine Reference | 11287629:1132 |
| Sentence | If binding of the GR to the eta-casein gene promoter is required to induce transcription, one might expect that HMG proteins would also be able to exert a similar effect as on the MMTV LTR. |
| CellLineName | HC11 |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i9 p1805 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/9/1805 |
| MedLine Reference | 12819296:1066 |
| Sentence | The half-palindromic GR binding sites in A?-casein gene promoter recruit GR molecules to the promoter ( 31 , 32 ). |
| Organism | Mus musculus |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v13 i2 p330 (1999) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/13/2/330 |
| MedLine Reference | 9973262:1295 |
| Sentence | It is still somewhat controversial whether or not GR binding to the A?A?-casein promoter is necessary for the observed transcriptional synergy between STAT5 and GR. |
| CellLineName | A 549 |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v24 i11 p4743 (2004) |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/11/4743 |
| MedLine Reference | 15143169:1285 |
| Sentence | Previously, an interactive mechanism had been reported for STAT and GR that promotes STAT phosphorylation and synergistic activation of the A?-casein gene by prolactin and glucocorticoids ( 38 ). |
| CellType | t cell |
|---|---|
| Journal | J. Immunol |
| Journal Reference | v164 i5 p2533 (2000) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/164/5/2533 |
| MedLine Reference | 10679091:1236 |
| Sentence | Consistent with this notion, a version of Stat5 capable of binding DNA, but lacking its TAD, can nevertheless interact with the glucocorticoid receptor to induce transcription of the A?A?-casein gene ( 34 , 35 ), thereby demonstrating that Stat5 is capable of TAD-independent transcriptional regulation. |
| Organism | Mus musculus |
| Tissue | mammary |
|---|---|
| MedLine Reference | 6687889:6 |
| Sentence | This indicates that pyridoxal-5'-P does not alter the specific hormone responsiveness of the mammary cells and its action mediated at the level of the glucocorticoid receptor can influence hormone-inducible expression of the casein genes. |
| Organism | Mus musculus |
| CellLineName | JEG3 |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v21 i20 p6859 (2001) |
| Journal Link | http://mcb.asm.org/cgi/content/full/21/20/6859 |
| MedLine Reference | 11564870:1245 |
| Sentence | STAT5 and GR cooperativity has been demonstrated previously for the activation of eta-casein gene expression in cotransfection experiments in several different cell types ( 14 , 50 , 58 ). |
| Organism | Mus musculus |
| CellLineName | COS |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v15 i2 p228 (2001) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/15/2/228 |
| MedLine Reference | 11158330:1149 |
| Sentence | These data indicate that the regions of GR that are necessary for transcriptional cooperation between STAT5 and GR and between C/EBPA?A? and GR in pairs are also necessary for transcriptional cooperation between all three transcription factors on the A?A?-casein promoter. |
| Tissue | milk |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v16 i9 p2008 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/9/2008 |
| MedLine Reference | 12198239:1297 |
| Sentence | Mol Endocrinol 13:330A?A?A?343 [Abstract/ Free Full Text] Wyszomierski SL, Rosen JM 2001 Cooperative effects of STAT5 (signal transducer and activator of transcription 5) and C/EBPA?A? (CCAAT/enhancer-binding protein-A?A?) on A?A?-casein gene transcription are mediated by the glucocorticoid receptor. |
| Organism | Mus musculus |
| Journal | PNAS |
|---|---|
| Journal Reference | v100 i11 p6517 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/11/6517 |
| MedLine Reference | 12754377:1185 |
| Sentence | This type of crosstalk has been described between STAT5 and the glucocorticoid receptor (GR), where GR has been demonstrated to enhance prolactin-induced STAT5-dependent transcription of the eta-casein promoter. |