| Entities | PCK2 ---- NR3C1 |
|---|---|
| References | 9 |
| Connectivity | 2 |
| Effect | unknown |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5106:inout-urn:agi-llid:2908::unknown |
| Tissue | thyroid |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v18 i4 p807 (2004) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/4/807 |
| MedLine Reference | 15044597:1029 |
| Sentence | Previous work suggests that these factors provide an environment that stabilizes GR binding to the PEPCK promoter ( 15 , 16 ). |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| MedLine Reference | 12118039:2 |
| Sentence | This GR activates PEPCK gene transcription at a 500-fold lower dexamethasone concentration than does wild type GR. |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i19 p13033 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/19/13033 |
| MedLine Reference | 10224054:1280 |
| Sentence | However, neither dimerization nor DNA binding of the glucocorticoid receptor is required for the glucocorticoid response of the PEPCK promoter ( 68 , 69 ). |
| Organism | Mus musculus |
| CellType | hepatocyte |
|---|---|
| CellLineName | OB |
| Organ | liver |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i41 p37991 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/41/37991 |
| MedLine Reference | 12107181:1052 |
| Sentence | Full transcriptional activation of the PEPCK promoter requires a coactivation of the glucocorticoid receptor and HNF4alpha ( 16 ). |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| MedLine Reference | 11557972:5 |
| Sentence | Full transcriptional activation of the PEPCK promoter requires coactivation of the glucocorticoid receptor and the liver-enriched transcription factor HNF-4alpha (hepatic nuclear factor-4alpha) by PGC-1. |
| Organism | Mus musculus |
| MedLine Reference | 11518712:0 |
|---|---|
| Sentence | Glucocorticoid induction of the phosphoenolpyruvate carboxykinase (PEPCK) gene requires a glucocorticoid response unit (GRU) comprised of two non-consensus glucocorticoid receptor (GR) binding sites, GR1 and GR2, and at least three accessory factor elements (gAF1-3). |
| Organism | Rattus norvegicus |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v13 i4 p604 (1999) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/13/4/604 |
| MedLine Reference | 10194766:1036 |
| Sentence | These results indicate that glucocorticoid-stimulated PEPCK gene transcription requires functional interactions between GR and the transactivation domains of at least two accessory factors, or between these two components and a third, coregulatory protein, and that these interactions require a specific spatial organization of the components of the GRU. |
| CellType | hepatocyte |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v18 i4 p820 (2004) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/4/820 |
| MedLine Reference | 14739255:1035 |
| Sentence | Ligand-activated GRalpha stimulates PEPCK promoter activity by cooperating with an orphan nuclear receptor, the chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and several other transcription factors by mechanisms that are as yet unclear ( 33 ). |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | Reg.Int.Comp.Phys |
| Journal Reference | v286 i3 pR554 (2004) |
| Journal Link | http://ajpregu.physiology.org/cgi/content/full/286/3/R554 |
| MedLine Reference | 14615274:1158 |
| Sentence | PGC-1 interacts with the hepatic nuclear factor-4alpha and the glucocorticoid receptor for fully activating PEPCK expression. |
| Organism | Rattus norvegicus |