| Entities | PRL ---- NR3C1 |
|---|---|
| References | 5 |
| Connectivity | 2 |
| Effect | unknown |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5617:inout-urn:agi-llid:2908::unknown |
| MedLine Reference | 2744462:4 |
|---|---|
| Sentence | Repression is dependent on the glucocorticoid receptor, which binds to the PLF promoter in a region that includes the AP-1 site, and the 31-bp phorbol ester 12-O-tetra decanoylphorbol-13-acetate (TPA)-inducible region is sufficient to mediate glucocorticoid repression. |
| Organism | Mus musculus |
| Organ | pituitar |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v145 i3 p1322 (2004) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/3/1322 |
| MedLine Reference | 14630718:1179 |
| Sentence | This experiment was designed to determine whether GR are involved in the induction of PRL cells. |
| CellLineName | HC11 |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i9 p1805 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/9/1805 |
| MedLine Reference | 12819296:1077 |
| Sentence | GR is known to enhance the PRL-induced DNA binding and transcriptional activity of Stat5 by increasing its tyrosine phosphorylation probably through modulating the rate of dephosphorylation ( 36 ). |
| Organism | Mus musculus |
| Organ | pituitar |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i26 p23838 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/26/23838 |
| MedLine Reference | 11331288:1329 |
| Sentence | Still other studies have demonstrated that interactions between PBX complexes and the glucocorticoid receptor mediate the inhibitory effect of glucocorticoids on prolactin transcription in non-pituitary cell lines ( 38 ). |
| Journal | PNAS |
|---|---|
| Journal Reference | v98 i23 p13055 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/23/13055 |
| MedLine Reference | 11606769:1164 |
| Sentence | Despite the higher contribution of jun proteins to the AP-1 complexes, and the noted positive cooperation of jun dimers with glucocorticoid receptor to stimulate transcription from a PLF gene-regulatory element ( 21 ), glucocorticoids continue to inhibit PLF gene expression. |
| Organism | Mus musculus |