| Entities | NR3C1 ---- POMC |
|---|---|
| References | 3 |
| Connectivity | 2 |
| Effect | unknown |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5443:inout-urn:agi-llid:2908::unknown |
| CellLineName | CRF |
|---|---|
| Organ | pituitar |
| MedLine Reference | 8994186:5 |
| Sentence | Finally, we provide evidence that the nurr1/nur77 response sequence is pivotal to both nurr1/nur77-dependent positive regulation and glucocorticoid receptor-dependent negative regulation of the POMC gene. |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v143 i8 p2961 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/8/2961 |
| MedLine Reference | 12130562:1335 |
| Sentence | For example, upon ligand-induced dimerization, the GR binds to an nGRE to repress the proopiomelanocortin gene expression ( 70 ). |
| MedLine Reference | 15591535:7 |
|---|---|
| Sentence | In vivo, GR and Nur factors can be coimmunoprecipitated whereas GR is recruited to the POMC promoter upon glucocorticoid action. |