| Entities | NR1I2 ---- NR3C1 |
|---|---|
| References | 8 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:8856:inout-urn:agi-llid:2908::positive |
| CellType | hepatocyte |
|---|---|
| Journal | Eur. J. Biochem |
| Journal Reference | v268 i24 p6346 (2001) |
| Journal Link | http://www.ejbiochem.org/cgi/content/full/268/24/6346 |
| MedLine Reference | 11737189:1034 |
| Sentence | In the low-concentration component (submicromolar concentrations), activation of the glucocorticoid receptor positively controls the expression of PXR and CAR which, in turn, activates CYP3A4 transcription in a ligand-independent manner. |
| CellType | hepatocyte |
|---|---|
| Journal | DMD |
| Journal Reference | v29 i10 p1325 (2001) |
| Journal Link | http://dmd.aspetjournals.org/cgi/content/full/29/10/1325 |
| MedLine Reference | 11560876:1020 |
| Sentence | Two nuclear receptors, pregnane X receptor (PXR) (Bertilsson et al., 1998 ; Blumberg et al., 1998 ; Kliewer et al., 1998 ) and the constitutively activated receptor (CAR) (Honkakoski et al., 1998 ), have recently been shown to mediate P450 gene induction in response to xenobiotics (Sueyoshi et al., 1999 ; Moore et al., 2000 ), and we have shown that the glucocorticoid receptor mediates PXR and CAR expression in human hepatocytes (Pascussi et al., 2000a ,b ). |
| Organism | Mus musculus |
| CellType | hepatocyte |
|---|---|
| MedLine Reference | 10860926:5 |
| Sentence | In addition to ligand-mediated activation of PXR, the overall induction response involves a GR-mediated stimulation of PXR and RXRalpha expression. |
| Organism | Rattus norvegicus |
| CellLineName | HuH7 |
|---|---|
| Organ | liver |
| Journal | DMD |
| Journal Reference | v31 i5 p620 (2003) |
| Journal Link | http://dmd.aspetjournals.org/cgi/content/full/31/5/620 |
| MedLine Reference | 12695351:1161 |
| Sentence | To test the hypothesis that activated GR could enhance PXR regulation of CYP2B6 gene expression by facilitating PXR activation of CYP2B6 reporter constructs, experiments were carried out in a liver-derived cell line (Huh7) transiently transfected with various plasmids. |
| CellType | hepatocyte |
|---|---|
| MedLine Reference | 12815172:4 |
| Sentence | A parallel down-regulation of mRNA expression of CAR, PXR, and tyrosine aminotransferase, a prototypic gene directly regulated by GR, was observed. |
| CellType | hepatocyte |
|---|---|
| Journal | Mol. Pharm |
| Journal Reference | v58 i6 p1441 (2000) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/58/6/1441 |
| MedLine Reference | 11093784:1083 |
| Sentence | In this respect, we recently reported that dexamethasone (ligand)-activated glucocorticoid receptor increases both hPXR and hRXRalpha mRNA expression and enhances PXR activator-mediated induction of CYP3A4 in human hepatocytes (Pascussi et al., 2000 ). |
| Organism | Mus musculus |
| Journal | DMD |
|---|---|
| Journal Reference | v29 i5 p615 (2001) |
| Journal Link | http://dmd.aspetjournals.org/cgi/content/full/29/5/615 |
| MedLine Reference | 11302925:1226 |
| Sentence | An open possibility is that the GR could interact with the PXR promoter transcription complex through protein-protein interactions. |
| CellLineName | HepG 2 |
|---|---|
| MedLine Reference | 15557560:8 |
| Sentence | Together, these results demonstrate a rational mechanistic basis for UGT1A1 induction by glucocorticoids and PXR activators, showing that activated GR enhances CAR/PXR-mediated UGT1A1 regulation with the transcriptional cofactor GRIP1 and that GR may be involved synergistically in the xenobiotic-responsive regulation of UGT1A1 by CAR/PXR. |