| Entities | CXADR ---- NR3C1 |
|---|---|
| References | 3 |
| Connectivity | 2 |
| Effect | unknown |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:2908:inout-urn:agi-llid:1525::unknown |
| CellType | hepatocyte |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i1 p42 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/1/42 |
| MedLine Reference | 12511605:1201 |
| Sentence | ChIP Assay to Detect the Binding of GR to the Distal Promoter of hCAR Gene in Human Hepatocytes Human hepatocytes were treated for 24 h with either dexamethasone (100 n M ) or DMSO (0.1%). |
| CellLineName | HuH7 |
|---|---|
| Journal | DMD |
| Journal Reference | v31 i5 p620 (2003) |
| Journal Link | http://dmd.aspetjournals.org/cgi/content/full/31/5/620 |
| MedLine Reference | 12695351:1230 |
| Sentence | Moreover, these studies have demonstrated that activated GR can also enhance hCAR-mediated constitutive expression of CYP2B6 reporter gene in Huh7 cells. |
| CellType | hepatocyte |
|---|---|
| Journal | Mol. Pharm |
| Journal Reference | v58 i6 p1441 (2000) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/58/6/1441 |
| MedLine Reference | 11093784:1231 |
| Sentence | Because the expression of CAR mRNA in response to dexamethasone parallels that of TAT mRNA, in terms of time course and concentration dependence, it is suggested that dexamethasone (ligand)-activated glucocorticoid receptor positively regulates hCAR gene expression. |
| Organism | Mus musculus |