| Transport Type | unknown |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-cas:30562-34-6:out-urn:agi-llid:2908::negative |
| Entities | geldanamycin ---| NR3C1 |
| References | 8 |
| Connectivity | 2 |
| Effect | negative |
| MedLine Reference | 12584114:1186 |
|---|---|
| CellType | hepatocyte |
| Sentence | Because GA affects GR stability ( 23 ), it seems logical that the lower GR response with cortisol may be due to a lower GR capacity. |
| Journal | Cell Phys |
| Journal Reference | v284 i6 pC1508 (2003) |
| Journal Link | http://ajpcell.physiology.org/cgi/content/full/284/6/C1508 |
| MedLine Reference | 11060043:1007 |
|---|---|
| Sentence | Using the glucocorticoid receptor ligand binding domain as a substrate, we show that dissociation of Hsp90 from bound polypeptide depends on the Hsp90 ATPase and is blocked by geldanamycin, a specific ATPase inhibitor. |
| Journal | EMBO |
| Journal Reference | v19 i21 p5930 (2000) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/19/21/5930 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12853476:1238 |
| Sentence | As expected, GA almost completely abolished the folding of GR, whereas the DMSO solvent control had no effect (Figure 7 B). |
| Journal | EMBO |
| Journal Reference | v22 i14 p3613 (2003) |
| Journal Link | http://embojournal.npgjournals.com/cgi/content/full/22/14/3613 |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 15070856:1182 |
| Sentence | Geldanamycin binds to HSP90 with high affinity and disrupts its function, thus preventing the efficient binding of glucocorticoids to MR and GR ( 33 , 35 ). |
| Journal | Endocrinology |
| Journal Reference | v145 i7 p3523 (2004) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/7/3523 |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 9228040:1011 |
| Sentence | Geldanamycin caused decreased levels of immunoreactive glucocorticoid receptors in wild-type cells with enhanced degradation occurring through the ubiquitin-proteasome pathway. |
| Journal | J. Biol. Chem |
| Journal Reference | v272 i30 p18694 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/30/18694 |
| MedLine Reference | 10894145:1097 |
|---|---|
| Sentence | Additional evidence for an Hsp90 role in GR recycling is provided by the observation that geldanamycin, a specific Hsp90-binding drug ( 59 ) and inhibitor of steroid receptor functions in vivo ( 60 61 62 63 64 65 ), can prevent release of hormone-withdrawn GR from high-affinity chromatin sites ( 66 ). |
| Journal | Mol. Endocrin |
| Journal Reference | v14 i7 p939 (2000) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/14/7/939 |
| MedLine Reference | 14551264:1033 |
|---|---|
| Sentence | Moreover, geldanamycin, a specific hsp90 inhibitor, prevents the release of the glucocorticoid receptor from chromatin in vivo ( 25 ). |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i12 p2543 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/12/2543 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 9849964:1113 |
| Sentence | We also observed that treatment of 3T3 cells with geldanamycin inhibited dexamethasone-mediated translocation of the endogenous GR visualized by indirect immunofluorescence. |
| Journal | Mol. Endocrin |
| Journal Reference | v12 i12 p1903 (1998) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/12/12/1903 |
| CellLineName | 3T3 |