Protein : PTPN6


Name	PTPN6
Description	protein tyrosine phosphatase, non-receptor type 6
Owner	Public
URN	urn:agi-llid:5777
Connectivity	205
Notes	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Three alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
Hugo ID	9658


Alias	hematopoietic phosphotyrosine phosphatase SHP-1
	SHP-1Ls
	sh2 phosphatase 1
	sh2 phosphatase I
	SH2-containing tyrosine phosphatase SHP-1
	Src homology domain 2-containing tyrosine phosphatase SHP-1
	PTP-1Cs
	HCPH
	Hematopoietic cell protein-tyrosine phosphatase
	hemopoietic cell phosphatase
	HPTP1C
	protein tyrosine phosphatase, non-receptor type 6
	Ptph6
	PTPN6
	SHP-1
	SHP-1L
	protein tyrosine phosphatase, non-receptor type VI
	protein-tyrosine phosphatase 1C
	SHP I
	70 kda SHP-1L protein
	PTP-1C
	SH-PTP1
	motheaten protein
	me
	hcp
	Ptp1C
	motheaten
	hematopoietic cell protein-tyrosine phosphatase
	Src homology domain 2 (SH2)-containing tyrosine phosphatase-1
	hematopoietic cell phophatase
	SH-PTP I
	mgc124580


FunctionalClass	phosphoprotein phosphatase
	phosphotyrosine binding
	prenylated protein tyrosine phosphatase
	hydrolase
	protein binding
	protein tyrosine phosphatase


RGD ID	620660


Hugo Symbol	PTPN6


Keyword	protein-tyrosine phosphatase
	sh-2 domain
	actin
	protein phosphatase
	protein tyrosine phosphatase activity
	protein tyrosine phosphatase
	protein phosphatase activity


GO Molecular Function	protein binding
	protein phosphatase activity
	protein tyrosine phosphatase activity
	prenylated protein tyrosine phosphatase activity
	hydrolase activity
	protein binding activity


Cell Localization	Cytoplasm


Pathway	PDGF signaling
	IL-3 signaling
	IL-1 and IL-6 signaling
	Erythropoietin signaling
	Jak-Stat Pathway from IL6 Receptor
	EGF
	AGT-LRP2
	AREG-EGFR
	BDNF-NTRK1
	BTC-EGFR
	CD86-CR1
	CNTF-LIFR
	CSF1-CSF1R
	CSF1-IL6R
	CSF1-TNFRSF5
	CSF3-CSF3R
	CSF3-IL6R
	DTR-EGFR
	EGF-NGFR
	EPO-EPOR
	EREG-EGFR
	F2-ITGAV
	F2-LRP1
	F2-LRP2
	F2-THBD
	FIGF-KDR
	GH1-IGF1R
	GRO1-EGFR
	IFNB1-IFNAR1
	IFNG-HLA-C
	IGF1-BST1
	IGF1-IGF2R
	IGF1-LRP5
	IL13-IL4R
	IL1B-HLA-DRB1
	IL1B-IL1R1
	IL1B-IL1RAP
	IL1B-IL6R
	IL2-IL4R
	IL3-CSF2RB2
	IL3-EPOR
	IL4-FCER2
	IL4-IL2RG
	IL4-IL4R
	IL5-IL6ST
	IL6-IL6R
	IL6-IL6ST
	IL6-LIFR
	IL6-TNFRSF5
	INS-EGFR
	KITLG-KIT
	LIF-IGF2R
	LIF-IL6ST
	LIF-LIFR
	NGFB-NGFR
	NGFB-NTRK1
	NGFB-NTRK2
	NGFB-NTRK3
	NRG1-EGFR
	NTF3-NTRK1
	NTF5-NTRK1
	OSM-CD22
	OSM-LIFR
	PGF-KDR
	PTH-IL6ST
	SDF1-IL6ST
	SELPLG-ICAM1
	TGFA-EGFR
	THPO-EPOR
	TNF-IL15RA
	TNF-NGFR
	TNF-TNFRSF1B
	VEGF-EGFR
	VEGFC-KDR
	Full DuPont
	DuPont 2
	DuPont 4
	Volcano 2
	CLA Grow
	FXR
	HNF4a
	Donna's proteomics


GO Biological Process	cytokine and chemokine mediated signaling pathway
	negative regulation of cell proliferation
	response to wounding
	G-protein coupled receptor protein signaling pathway
	apoptosis
	intracellular signaling cascade
	protein amino acid dephosphorylation
	signal transduction


EC Number	3.1.3.48


State Description	Transcript Variant: This variant (1) lacks an internal fragment within the coding region, which leads to a translation frame change when compared to variant 3. It encodes a protein that has an identical N-terminus and a different C-terminus, as compare...
	Transcript Variant: This variant (2) contains a different 5' end region including 5' UTR and a small portion of the coding region, and lacks an internal fragment within the coding region, when compared to variant 3. The internal fragment missing leads ...
	Transcript Variant: This variant (3) encodes the longest isoform (3).


MGI ID	96055


Swiss-Prot Accession	P29350


OMIM ID	176883
	OMIM:176883