| Name | UGT2B4 |
|---|---|
| Description | UDP glucuronosyltransferase 2 family, polypeptide B4 |
| Owner | Public |
| URN | urn:agi-llid:7363 |
| Connectivity | 2 |
| Notes | Farnesoid X receptor (FXR) induces the UGT2B4 enzyme in hepatocytes; this study identifies UGT2B4 as a novel FXR target gene. P.1053: ""...UGT2B4...is...fairly common in Caucasians...and Africans...""but...still rare in ...Japanese..."" P.1054: ""...genotyping UGT2B4...in Japanese...would be useful for studies on... association between haplotypes and pharmacokinetic...parameters. UGT2B4 expression is regulated by PPARalpha. |
| Microarray ID | A_23_P386911 |
|---|---|
| A_14_P115969 | |
| A_23_P386912 | |
| A_23_P335214 | |
| H347 | |
| OH9443 | |
| OR1524A | |
| RT043 | |
| 1368397_at | |
| u06274_s_at | |
| 37058_at | |
| 206505_at | |
| Y00317_at | |
| rc_n53031_s_at |
| Chromosome position | 4q13 |
|---|---|
| 14p21 |
| GO ID | 0005783 |
|---|---|
| 0005792 | |
| 0006711 | |
| 0006805 | |
| 0008152 | |
| 0015020 | |
| 0016021 | |
| 0016740 | |
| 0016757 | |
| 0016758 |
| Alias | UGT2B4 |
|---|---|
| HLUG25 | |
| AI788959 | |
| UDP-glucuronyltransferase, family 2, beta-4 | |
| HLUG25s | |
| expressed sequence AI788959 | |
| MGC37823 | |
| UDP-glucuronosyltransferase 2B4 precursor, microsomal | |
| UDPGTH-1 | |
| UDP-glucuronyltransferase, family 2, beta- | |
| UDP glycosyltransferase 2 family, polypeptide B4 | |
| UDPGTH I | |
| UDP-glucuronyltransferase, family 2, beta IV |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus |
| MedLine Reference | 7574722 |
|---|---|
| 8333863 |
| LocusLink ID | 83808 |
|---|---|
| 7363 |
| FunctionalClass | glucuronosyltransferase |
|---|---|
| transferase | |
| transferase activity, transferring glycosyl groups | |
| transferase activity, transferring hexosyl groups |
| KEGG pathway | Androgen and estrogen metabolism |
|---|---|
| Pentose and glucuronate interconversions | |
| Porphyrin and chlorophyll metabolism | |
| Starch and sucrose metabolism |
| GO Cellular Component | endoplasmic reticulum |
|---|---|
| integral to membrane | |
| microsome |
| Cell Localization | Endoplasmic reticulum |
|---|
| Pathway | PPAR all |
|---|---|
| FXR | |
| PPARalpha | |
| NR common targets |
| GO Biological Process | estrogen catabolism |
|---|---|
| metabolism | |
| xenobiotic metabolism |
| Group | Glycosyltransferases |
|---|
| EC Number | 2.4.1.17 |
|---|