| Name | NR5A2 |
|---|---|
| Description | nuclear receptor subfamily 5, group A, member 2 |
| Owner | Public |
| URN | urn:agi-llid:2494 |
| Connectivity | 32 |
| Notes | CYP11A1 expression in human granulosa cells is regulated by LRH-1. Data show that sumoylated LRH-1 is exclusively localized in promyelocytic leukemia protein nuclear bodies, and that this association is a dynamic process regulated in part by SUMO-1. Human LRH-1 receptor binds phosphatidyl inositol second messengers;ligand binding is required for maximal activity. LHR-1 regulgates apolipoprotein A-1 transscription, and affects cholesterol homeostasis. LRH-1 could be the major transcription factor responsible for the rapid and significant increase in ovarian StAR gene expression after ovulation. LRH-1 is a nuclear receptor which can assume an active conformation in the absence of a ligand agonist. LRH-1 is a positive transcription factor for ABCG5 and ABCG8 and, in conjunction with studies on LRH-1 activation of other promoters, identify LRH-1 as a ""master regulator"" for genes involved in sterol and bile acid secretion from liver and intestine. LRH-1 is highly expressed in corpus luteum, and it plays an essential role in the regulation of HSD3B2. Ligands are dispensabe for LRH-1 activation. Liver receptor homolog 1 controls the expression of carboxyl ester lipase in pancreas. PDX-1 regulates expression of LRH-1 during pancreas development. The liver receptor homolog-1 has emerged as an essential regulator for the expression of cyp7a1 gene. B1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus. HBIF and HNF1 are involved together in the viral gene expression regulation of the Hepatitis B virus. HLRH-1's control of gene expression is mediated by phospholipid binding. Important functional role of helix 1 in cofactor recruitment and a novel molecular mechanism of transcriptional regulation and cofactor recruitment mediated by hLRH-1. Role for LRH-1 in the induction of the progesterone but not the estrogen biosynthetic pathway during granulosa cell differentiation. Role in regulating aromatase expression in preadipocytes (liver receptor homologue-1). |
| Microarray ID | 1449707_at |
|---|---|
| msa.911.0_at | |
| A_51_P514449 | |
| U93553 | |
| U80251 | |
| 210174_at | |
| 35865_at | |
| 59241_at | |
| 208337_s_at | |
| 208343_s_at | |
| 1560469_at | |
| U93553_at | |
| A_14_P126842 | |
| A_14_P131751 | |
| A_14_P134233 | |
| A_14_P116960 | |
| A_14_P109851 | |
| A_23_P993 | |
| A_32_P863837 | |
| A_23_P160996 | |
| A_24_P920090 | |
| A_23_P161004 | |
| OH0935A | |
| OR1636A | |
| MA493 | |
| 1387573_a_at | |
| ab012960_s_at | |
| A_43_P12110 | |
| 1420410_at | |
| 1449706_s_at |
| Chromosome position | 1 78.0 cM |
|---|---|
| 13q13 | |
| 4 D2.3 | |
| 3 F1 | |
| 1q32.1 |
| GO ID | 0016563 |
|---|---|
| 0005764 | |
| 0016021 | |
| 0003677 | |
| 0003700 | |
| 0004872 | |
| 0004879 | |
| 0005667 | |
| 0008206 | |
| 0042632 | |
| 0003705 | |
| 0003707 | |
| 0005634 | |
| 0006350 | |
| 0006355 | |
| 0006366 | |
| 0009653 | |
| 0046872 |
| Alias | HB1F-2 |
|---|---|
| Hepatocytic transcription factor | |
| LRH-1 | |
| Nr5a2 | |
| Orphan nuclear receptor NR5A2 | |
| CYP7A promoter binding factor | |
| lysosomal-associated protein transmembrane V | |
| D1Ertd308e | |
| FTZ-F I | |
| LRH I | |
| HB1F II | |
| Lysosomal-associated multispanning membrane protein V | |
| b1-binding factor, hepatocyte transcription factor which activates enhancer | |
| FTZ-F1beta | |
| nuclear receptor subfamily 5, group A, member 2 | |
| fetoprotein transcription factor | |
| Doi 308s | |
| FTZ-F1s | |
| nuclear receptor nr5a2 | |
| liver receptor homolog 1 | |
| LAPTM5s | |
| liver receptor homolog I | |
| FTZ-F Is | |
| cpf | |
| nuclear receptor subfamily 5, group A, member II | |
| Doi 308 | |
| B1F2 | |
| Alpha-1-fetoprotein transcription factor | |
| B1-binding factor | |
| fetoprotein-alpha 1 (AFP) transcription factor | |
| FTZ-F1 | |
| FTZ-F1 beta1 protein | |
| FTZ-F1 beta2 protein | |
| HB1F |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MedLine Reference | 8668203 |
|---|---|
| 12466851 | |
| 15014077 | |
| 9786908 |
| LocusLink ID | 60349 |
|---|---|
| 29612 | |
| 60348 | |
| 14318 | |
| 26424 | |
| 8768 | |
| 29854 | |
| 2494 | |
| 16792 | |
| 52226 | |
| 68911 |
| FunctionalClass | transcriptional activator |
|---|---|
| DNA binding | |
| ligand-dependent nuclear receptor | |
| receptor | |
| transcription factor | |
| RNA polymerase II transcription factor activity, enhancer binding | |
| metal ion binding | |
| steroid hormone receptor |
| GO Cellular Component | nucleus |
|---|---|
| transcription factor complex | |
| integral to membrane | |
| lysosome |
| Cell Localization | Plasma membrane |
|---|---|
| Nucleus |
| Pathway | FXR |
|---|---|
| LRH-1 | |
| HNF4a | |
| NR common targets | |
| NR common regulators | |
| NR CYP ABCs | |
| NR target genes |
| GO Biological Process | morphogenesis |
|---|---|
| regulation of transcription, DNA-dependent | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| bile acid metabolism | |
| cholesterol homeostasis |
| Group | Nuclear receptors |
|---|---|
| Nrs |
| Source | Curated |
|---|