| Name | CARM1 |
|---|---|
| Description | coactivator-associated arginine methyltransferase 1 |
| Owner | Public |
| URN | urn:agi-llid:10498 |
| Connectivity | 15 |
| Notes | CARM1 affects pre-mRNA splicing in an isoform-specific manner. CARM1 plays a significant role in promoting the differentiation of early thymocyte progenitors, possibly through its direct action on TARPP. Methylates PAB1 and TARPP, suggesting a role in regulating transcription/translation. The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, there is a crosstalk between lysine acetylation and arginine methylation on chromatin. Overexpression of CARM1 is involved in the development of prostate carcinoma. Results show that CARM1/PRMT4 is a novel transcriptional coactivator of NF-kappaB and functions as a promoter-specific regulator of NF-kappaB recruitment to chromatin. |
| Microarray ID | A_32_P395055 |
|---|---|
| A_14_P111121 | |
| 1419743_s_at | |
| 1438415_s_at | |
| A_51_P370390 | |
| A_52_P119883 | |
| 221939_at | |
| 40182_s_at | |
| 212512_s_at |
| Chromosome position | 19p13.2 |
|---|
| GO ID | 0003713 |
|---|---|
| 0005515 | |
| 0005634 | |
| 0005737 | |
| 0006355 | |
| 0008276 | |
| 0008757 | |
| 0016568 | |
| 0016571 | |
| 0016740 | |
| 0006350 | |
| 0008168 | |
| 0008469 |
| Alias | MGC46828 |
|---|---|
| PRMT4 | |
| CARM I | |
| CARM1 | |
| coactivator-associated arginine methyltransferase I | |
| coactivator-associated arginine methyltransferase-1 | |
| protein arginine methyltransferase |
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MedLine Reference | 15221992 |
|---|---|
| 10381882 | |
| 12466851 |
| LocusLink ID | 10498 |
|---|---|
| 215691 | |
| 59035 |
| FunctionalClass | S-adenosylmethionine-dependent methyltransferase |
|---|---|
| protein binding | |
| protein methyltransferase | |
| transcription coactivator | |
| transferase | |
| histone-arginine N-methyltransferase | |
| methyltransferase |
| GO Cellular Component | cytoplasm |
|---|---|
| nucleus |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| Pathway | FXR |
|---|
| GO Biological Process | chromatin modification |
|---|---|
| histone methylation | |
| regulation of transcription, DNA-dependent | |
| transcription |
| Group | Methyltransferases |
|---|
| Source | Curated |
|---|