| Name | SDC1 |
|---|---|
| Description | syndecan 1 |
| Owner | Public |
| URN | urn:agi-llid:6382 |
| Connectivity | 26 |
| Notes | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. |
| Hugo ID | 10658 |
| Microarray ID | 1367849_at |
|---|---|
| s61865_s_at | |
| x60651mrna_s_at | |
| A_42_P677580 | |
| A_43_P14872 | |
| 1415943_at | |
| 1415944_at | |
| 1437279_x_at | |
| 1448158_at | |
| 161370_f_at | |
| 94670_f_at | |
| 96033_at | |
| msa.2710.0_s_at | |
| z22532_at | |
| A_51_P371923 | |
| A_52_P479269 | |
| 75293_s_at | |
| 201286_at | |
| 201287_s_at | |
| Z48199_at | |
| 38127_at | |
| rc_r82074_f_at | |
| A_23_P16944 | |
| A_14_P126493 | |
| A_24_P97129 | |
| OR1452 | |
| OH3023 | |
| RT273 | |
| V405 |
| Chromosome position | 6q14 |
|---|---|
| 12 1.0 cM | |
| 15 D1 | |
| 2p24.1 |
| GO ID | 0005615 |
|---|---|
| 0016021 | |
| 0007155 | |
| 0007267 | |
| 0005887 | |
| 0008092 | |
| 0016020 |
| Alias | SDC |
|---|---|
| SYNDECAs | |
| Synd | |
| SYNDECA | |
| syndecan 1 | |
| AA408134 | |
| BM-009 | |
| SDC1_HUMAN | |
| CD138 | |
| SYND1 | |
| syndecan I | |
| SDC I | |
| hypothetical protein BM-009 | |
| SYND I | |
| CD138 antigen | |
| SDC1 |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 2324102 |
|---|---|
| 12466851 | |
| 12135485 |
| LocusLink ID | 6382 |
|---|---|
| 25543 | |
| 20969 | |
| 106027 | |
| 109056 | |
| 117121 | |
| 223601 | |
| 76270 | |
| 25216 | |
| 104717 | |
| 104719 |
| FunctionalClass | cytoskeletal protein binding |
|---|
| RGD ID | 3648 |
|---|
| Hugo Symbol | SDC1 |
|---|
| Unigene ID | Rn.11176 |
|---|---|
| Mm.2580 | |
| Hs.224607 |
| KEGG pathway | ECM-receptor interaction |
|---|
| GO Cellular Component | integral to plasma membrane |
|---|---|
| membrane | |
| extracellular space | |
| integral to membrane |
| Cell Localization | Plasma membrane |
|---|---|
| Cytoplasm |
| Pathway | EGF-ERBB3 |
|---|---|
| EGF-ERBB4 | |
| EGF-LRP8 | |
| EGF-NGFR | |
| F2-ITGAV | |
| F2-LRP1 | |
| F2-LRP2 | |
| NUDT6-FGFR1 | |
| TAC1-TNFRSF11B | |
| TGFB1-ACVR1 | |
| TGFB1-ACVR1B | |
| TGFB1-ACVR2 | |
| TGFB1-ACVR2B | |
| TGFB1-ACVRL1 | |
| TGFB1-BMPR1B | |
| TGFB1-IGF2R | |
| TGFB1-IL6R | |
| TGFB1-M6PR | |
| TGFB1-SELE | |
| TGFB1-SELL | |
| TGFB1-TGFBR1 | |
| TGFB1-TGFBR2 | |
| TGFB1-TGFBR3 | |
| TNFSF11-TNFRSF11B | |
| FXR |
| GO Biological Process | cell adhesion |
|---|---|
| cell-cell signaling |
| State | precursor |
|---|
| State Description | Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. |
|---|---|
| Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. |
| MGI ID | 1349162 |
|---|
| Swiss-Prot Accession | P18827 |
|---|
| OMIM ID | 186355 |
|---|
| Source | Curated |
|---|